Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer
Table 2
Association between clinicopathological variables and ALDH1 immunoexpression in patients with subtypes of oral cancer.
Variable
ALDH1 immunoexpression in subtypes of oral cancer
WDOSCC
p
PDOSCC
p
BSCC
p
(−)
(+)
(−)
(+)
(−)
(+)
N (%)
N (%)
N (%)
N (%)
N (%)
N (%)
Gender
Male
9 (50.0)
2 (100)
0.479
9 (75.0)
5 (100)
0.515
9 (90.0)
7 (77.3)
0.582
Female
9 (50.0)
0
3 (25.0)
0
1 (10.0)
2 (22.2)
Age
≤60 years
8 (44.4)
2 (100)
0.474
7 (58.3)
4 (80.0)
0.600
4 (40.0)
2 (22.2)
0.628
>60 years
10 (55.8)
0
5 (41.7)
1 (20.0)
6 (60.0)
7 (77.8)
Tobacco
Yes
6 (75.0)
2 (100)
1.000
6 (85.7)
5 (100)
1.000
6 (85.7)
6 (100)
1.000
No
2 (25.0)
0
1 (14.3)
0
1 (14.3)
0
Alcohol
Yes
5 (55.6)
2 (100)
0.491
6 (100)
5 (100)
NC
4 (66.7)
5 (83.3)
1.000
No
4 (44.4)
0
0
0
2 (33.8)
1 (16.7)
T stage
T1-T2
10 (55.6)
1 (50.0)
1.000
1 (8.3)
1 (20.0)
0.515
4 (40.0)
2 (22.2)
0.628
T3-T4
8 (44.4)
1 (50.0)
11 (91.7)
4 (80.0)
6 (60.0)
7 (77.8)
N stage
N0
14 (77.8)
2 (100)
1.000
4 (33.3)
1 (20.0)
1.000
4 (44.4)
1 (11.1)
0.294
N+
4 (22.2)
0
8 (66.7)
4 (80.0)
5 (55.6)
8 (88.9)
Radiotherapy
Yes
4 (22.2)
2 (100)
0.079
10 (83.3)
4 (80.0)
1.000
6 (60.0)
8 (88.9)
0.303
No
14 (77.8)
0
2 (16.7)
1 (20.0)
4 (40.0)
1 (11.1)
Recurrence
Yes
7 (38.9)
0
0.521
5 (41.7)
3 (60.0)
0.620
7 (70.0)
6 (66.7)
1.000
No
11 (61.1)
2 (100)
7 (58.3)
2 (40.0)
3 (30.0)
3 (33.3)
Angiolymphatic invasion
Yes
3 (17.6)
0
1.000
2 (18.2)
1 (20.0)
1.000
3 (30.0)
4 (44.4)
0.650
No
14 (82.5)
2 (100)
9 (81.8)
4 (80.0)
7 (70.0)
5 (55.6)
Perineural infiltration
Yes
8 (47.1)
1 (50.0)
1.000
8 (72.7)
2 (40.0)
0.299
4 (44.4)
1 (11.1)
0.294
No
9 (52.9)
1 (50.0)
3 (27.3)
3 (60.0)
5 (55.6)
8 (88.9)
Lymph node (pN)
Yes
3 (25.0)
0
1.000
8 (66.7)
3 (75.0)
1.000
5 (62.5)
6 (66.7)
1.000
No
9 (75.0)
2 (100.0)
4 (33.3)
1 (25.0)
3 (37.5)
3 (33.3)
WDOSCC, well-differentiated oral squamous cell carcinoma; PDOSCC, poorly differentiated squamous cell carcinoma; BSCC, basaloid squamous cell carcinoma; N, number of tumors; NC, not calculated. Analysis by chi-square test or Fischer’s exact test. < 0.05 was considered statistically significant. Excluded patients without records.
