Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer
Table 3
Association between clinicopathological variables and Notch1 immunoexpression in patients with subtypes of oral cancer.
Variable
Notch1 immunoexpression in subtypes of oral cancer
WDOSCC
p
PDOSCC
p
BSCC
p
(−)
(+)
(−)
(+)
(−)
(+)
N (%)
N (%)
N (%)
N (%)
N (%)
N (%)
Gender
Male
7 (77.8)
4 (36.4)
0.092
7 (70.0)
7 (100)
0.228
11 (84.6)
5 (83.3)
1.000
Female
2 (22.2)
7 (63.6)
3 (30.0)
0
2 (15.4)
1 (16.7)
Age
≤60 years
5 (55.6)
4 (36.4)
1.000
7 (70.0)
4 (57.1)
0.644
4 (30.8)
2 (33.3)
1.000
>60 years
4 (44.4)
7 (63.3)
3 (30.0)
3 (42.9)
9 (69.2)
4 (66.7)
Tobacco
Yes
2 (100)
6 (75.0)
1.000
7 (87.5)
4 (100)
1.000
8 (88.9)
4 (100)
1.000
No
0
2 (25.0)
1 (12.5)
0
1 (11.1)
0
Alcohol
Yes
3 (100)
4 (50.0)
0.236
7 (100)
4 (100)
NC
7 (87.5)
2 (50.0)
0.236
No
0
4 (50.0)
—
—
1 (12.5)
2 (50.0)
T stage
T1-T2
6 (66.7)
5 (45.5)
0.406
2 (20.0)
0
0.485
5 (38.5)
1 (16.7)
0.605
T3-T4
3 (33.3)
6 (54.5)
8 (80.0)
7 (100)
8 (61.5)
5 (83.3)
N stage
N0
8 (88.9)
8 (72.7)
0.591
4 (40.0)
1 (14.3)
0.338
2 (16.7)
3 (50.0)
0.268
N+
1 (11.1)
3 (27.3)
6 (60.0)
6 (85.7)
10 (83.3)
3 (50.0)
Radiotherapy
Yes
3 (33.3)
3 (27.3)
1.000
8 (80.0)
6 (85.7)
1.000
10 (76.9)
4 (66.7)
1.000
No
6 (66.7)
8 (72.7)
2 (20.0)
1 (14.3)
3 (23.1)
2 (33.3)
Recurrence
Yes
5 (55.6)
2 (18.2)
0.160
4 (40.0)
4 (57.1)
0.637
10 (76.9)
3 (50.0)
0.320
No
4 (44.4)
9 (81.8)
6 (60.0)
3 (42.9)
3 (23.1)
3 (50.0)
Angiolymphatic invasion
Yes
1 (12.5)
2 (18.2)
1.000
1 (11.1)
2 (28.6)
0.550
5 (38.5)
2 (33.3)
1.000
No
7 (87.5)
9 (81.8)
8 (88.9)
5 (71.4)
8 (61.5)
4 (66.7)
Perineural infiltration
Yes
5 (62.5)
4 (36.4)
0.370
3 (33.3)
7 (100)
0.011
4 (33.3)
1 (16.7)
0.615
No
3 (37.5)
7 (63.6)
6 (66.7)
0
8 (66.7)
5 (83.3)
Lymph node (pN)
Yes
1 (20.0)
2 (22.2)
1.000
4 (44.4)
7 (100)
0.034
8 (66.7)
3 (60.0)
1.000
No
4 (80.0)
7 (77.8)
5 (55.6)
0
4 (33.3)
2 (40.0)
WDOSCC, well-differentiated oral squamous cell carcinoma; PDOSCC, poorly differentiated squamous cell carcinoma; BSCC, basaloid squamous cell carcinoma; N, number of tumors; NC, not calculated. Analysis by chi-square test or Fischer’s exact test. < 0.05 was considered statistically significant. Excluded patients without records.
