Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer

Table 4

Overall survival (OS) and disease-free survival (DFS) rates in 5 years of 63 patients with subtypes of oral cancer according to the clinicopathological variables, and ALDH1 and Notch1 immunoexpression.

Variable		Overall survival		Disease-free survival
		5 years (%)	p	5 years (%)	p
Tobacco	No	66.7	0.407	83.3	0.228
	Yes	46.6		48.9
Alcohol	No	75.0	0.298	62.5	0.901
	Yes	49.9		60.4
Tumor site	Tongue/floor of mouth	40.6	0.024	54.1	0.716
	Palate	85.7		57.1
	Retromolar/gingiva	40.6		49.2
	Others	0		76.2
T stage	T1-T2	75.5	0.005	65.2	0.276
	T3-T4	39.2		50.5
N stage	N0	72.4	0.001	73.5	0.005
	N+	31.5		34.9
Histologic grade	WDOSCC + VC	78.1	0.001	79.6	0.004
	PDOSCC + BSCC	34.7		37.6
Radiotherapy	No	70.7	0.028	75.1	0.037
	Yes	39.6		42.0
Perineural invasion	No	55.9	0.471	54.6	0.844
	Yes	44.9		55.3
Lymph node (pN)	No	59.1	0.045	70.1	0.024
	Yes	32.6		34.7
ALDH1	Negative/weak	61.7	0.040	59.6	0.458
	Strong	31.3		46.2
Notch1	Negative/weak	49.9	0.810	48.0	0.110
	Strong	55.6		68.3

WDOSCC, well-differentiated oral squamous cell carcinoma; VC, verrucous carcinoma; PDOSCC, poorly differentiated squamous cell carcinoma; BSCC, basaloid squamous cell carcinoma. value obtained by log-rank test.  < 0.05 was considered statistically significant. The values highlighted in bold show that they were statistically significant.