Development and Validation of a Nomogram Based on Noninvasive Liver Reserve and Fibrosis (PALBI and FIB-4) Model to Predict Posthepatectomy Liver Failure Grade B-C in Patients with Hepatocellular Carcinoma

Table 2

Univariate and multivariable analyses to identify factors predicting PHLF grade B-C.

Variables	Univariate logistic regression			Multivariable logistic regression
	β	Odds ratio	value	β	Odds ratio	value
Age (years)	0.024	1.025	0.056
Sex (male)	0.365	1.440	0.365
Serum ALP (IU/L)	<0.001	1.000	0.894
Serum γ-GGT (IU/L)	0.001	1.001	0.069
Positive HBsAg	−0.224	0.783	0.493
Cirrhosis	1.118	3.060	<0.001	0.831	2.296	0.026
Major hepatectomy	0.795	2.214	0.005	0.794	2.211	0.031
AFP (>400 ng/mL)	0.005	1.005	0.986
Tumour size (>5 cm)	0.512	1.688	0.073
Tumour number (multiple)	0.920	2.508	0.003	0.649	1.913	0.090
Ascites	1.420	4.138	0.001	1.278	3.588	0.014
Intraoperative blood loss (>400 mL)	1.355	3.878	<0.001	1.544	4.683	<0.001
PALBI score (>−2.53)	2.081	8.015	<0.001	1.283	3.609	0.005
FIB-4 score (≥1.45)	2.104	8.201	<0.001	1.661	2.077	<0.001

Abbreviations: ALP, alkaline phosphatase; γ-GGT, γ-glutamyl transpeptidase; HbsAg, hepatitis B surface antigen; AFP, alpha fetoprotein; PALBI, platelet-albumin-bilirubin; FIB-4, fibrosis-4 index.