Correlates of Long-Term Survival of Patients with pN+ Esophageal Squamous Cell Carcinoma after Esophagectomy

Table 2

Results of univariate analysis showing factors associated with survival of patients with pN + ESCC.

Factors	N.	OS			DFS			LRFS
		3-year	5-year		3-year	5-year		3-year	5-year
Gender
Male	338	34.0	23.9	0.040	25.2	18.8	0.115	40.1	34.0	0.199
Female	115	36.5	30.3		29.6	25.1		48.1	44.7
Age
≤60 years	247	37.6	28.0	0.084	26.0	21.9	0.349	40.0	35.9	0.510
>60 years	206	31.1	22.7		26.7	18.8		54.2	38.2
Site of lesion
Upper	40	47.5	30.0	0.047	38.6	25.8	0.011	48.9	45.6	0.070
Middle	312	30.0	22.3		22.4	17.3		39.8	33.1
Lower	101	42.5	34.2		33.6	28.1		47.1	44.0
Length of lesion
<6 cm	219	37.0	26.5	0.415	28.3	22.6	0.140	42.1	35.7	0.965
≥6 cm	234	32.4	24.7		24.5	18.4		42.4	38.4
Resected LN
<12	264	31.8	23.6	0.045	23.9	18.8	0.169	41.8	37.5	0.656
≥12	189	38.6	28.2		29.8	22.7		42.5	35.7
Surgery
Two-field	430	33.5	24.4	0.071	25.3	19.3	0.202	41.8	38.9	0.322
Three-field	23	56.5	47.8		45.9	41.3		50.5	50.5
Differentiation
Well-middle	331	34.4	25.0	0.603	25.2	19.4	0.196	42.6	37.8	0.935
Poor	122	35.2	27.3		29.5	23.1		41.4	34.8
pT
pT2	57	45.6	34.4	0.007	31.6	24.9	0.003	38.6	35.4	0.121
pT3	367	34.6	25.3		27.1	20.8		44.9	38.8
pT4	29	13.8	13.8		6.9	6.9		16.3	16.3
pN
pN1	294	42.2	32.4	<0.001	32.4	25.1	<0.001	47.6	40.6	<0.001
pN2	131	23.7	15.1		17.6	13.6		34.0	32.3
pN3	28	7.1	3.6		3.6	3.6		10.3	10.3
pTNM
IIb	42	50.0	42.7	<0.001	35.7	29.2	<0.001	38.3	34.8	<0.001
IIIa	250	41.2	30.2		32.5	24.4		51.1	43.0
IIIb	108	25.0	17.6		18.5	14.8		35.5	33.6
IIIc	53	11.3	9.1		5.7	5.7		13.2	13.2
Adjuvant therapy
No	131	20.6	15.2	<0.001	15.4	13.1	<0.001	31.4	28.4	<0.001
POCT	222	36.5	28.0		27.5	20.8		39.6	33.5
PORT	57	43.9	27.4		29.8	24.2		53.1	53.1
POCRT	43	55.7	42.8		48.8	35.5		69.2	57.0
NLR
<3.5	314	38.5	28.7	0.002	27.8	22.2	0.070	42.3	37.5	0.473
≥3.5	139	259	18.5		23.0	16.5		42.0	35.3
LMR
≤3.5	233	30.4	21.9	0.033	22.9	18.3	0.043	40.4	34.9	0.154
>3.5	220	39.1	29.5		30.0	22.6		44.1	38.9

LN: lymph node; POCRT: postoperative chemoradiotherapy; POCT: postoperative chemotherapy; PORT: postoperative radiotherapy; NLR: neutrophil lymphocyte ratio; LMR: lymphocyte monocyte rate.