Ferroptosis-Related Gene Model to Predict Overall Survival of Ovarian Carcinoma

Table 2

Univariable and multivariable cox regression analysis of the nine ferroptosis-related gene signature and survival analysis of OC patients in the TCGA training, test set, and ICGC cohort.

Variables			The training set (n = 189)				The test set (n = 188)				The ICGC set (n = 93)
			HR	95% CI of HR			HR	95% CI of HR			HR	95% CI of HR
				Lower	Upper			Lower	Upper			Lower	Upper
Univariate analysis	Age	≥60 vs <60	1.166	0.905	1.501	0.235	1.156	0.883	1.513	0.292	1.169	0.842	1.622	0.352
	Race	White vs others	0.715	0.449	1.138	0.157	0.665	0.444	0.995	0.047	—	—	—	—
	Stage	III, IV vs I, II	1.758	0.781	3.958	0.173	1.682	0.746	3.797	0.21	0.686	0.408	1.154	0.156
	Grade	G3, G4 vs G1, G2	1.074	0.732	1.577	0.715	1.279	0.835	1.959	0.258	—	—	—	—
	Tumor status	Tumor vs tumor-free	5.067	2.244	11.441	<0.001	7.222	2.654	19.655	<0.001	—	—	—	—
	Risk score	High vs low	2.657	1.823	3.872	<0.001	1.887	1.287	2.768	0.001	3.115	1.914	5.069	<0.001
Multivariable analysis	Age	≥60 vs <60	1.09	0.822	1.443	0.55	1.201	0.897	1.607	0.218	1.193	0.857	1.66	0.297
	Race	White vs others	0.707	0.429	1.165	0.174	0.668	0.437	1.02	0.062	—	—	—	—
	Stage	III, IV vs I, II	1.742	0.729	4.163	0.211	1.292	0.474	3.523	0.616	0.79	0.466	1.338	0.38
	Grade	G3, G4 vs G2, G1	0.986	0.63	1.541	0.949	1.115	0.69	1.803	0.657	—	—	—	—
	Tumor status	Tumor vs tumor-free	4.58	2.017	10.401	<0.001	7.672	2.803	20.996	<0.001	—	—	—	—
	Risk score	High vs low	1.767	1.155	2.704	0.009	1.944	1.271	2.973	0.002	3.06	1.865	5.021	<0.001