Activity and Safety of Tegafur, Gimeracil, and Oteracil Potassium for Nasopharyngeal Carcinoma: A Systematic Review and Meta-Analysis

Table 2

Trim-and-fill method for complete remission.

Step 1^a
Model	Pooled estimate	95% CI		Asymptotic
		Lower limit	Upper limit	z value	value	Studies (n)
Fixed	0.853	0.595	1.111	6.483	0	23
Random	0.866	0.587	1.144	6.096	0
Test for heterogeneity: Q = 24.331 on 22 degrees of freedom ()
Moment-based estimate of between-studies variance = 0.043
Step 2^b
Trimming estimator: linear
Meta-analysis type: random effect model
Iteration	Estimate	Tn		# to trim		Diff
1	0.866	184		4		276
2	0.796	197		5		26
3	0.79	200		6		6
4	0.784	200		6		0
Step 3^c
Filled meta-analysis
Model	Pooled	95% CI		Asymptotic		Studies (n)
	Estimate	Lower limit	Upper limit	z value	value
Fixed	0.78	0.529	1.03	6.104	0	29
Random	0.783	0.515	1.051	5.726	0

^aMeta-analysis was performed by combined results of all effects with a fixed model and random model. ^bThe trimming estimator of the random-effect model (through four iterations). ^cMeta-analysis was performed again after the inclusion of the missing studies.