Plant-Derived Chinese Medicine Monomers on Ovarian Cancer via the Wnt/β-Catenin Signaling Pathway: Review of Mechanisms and Prospects

Table 1

Mechanism of plant-derived Chinese medicine monomers on OC via the Wnt/β-catenin signaling pathway.

Plant-derived Chinese medicines	Targets	Mechanism	Refs.
Resveratrol	c-Myc, cyclin A, cyclin D1, N-cadherin, vimentin, β-catenin, E-cadherin, p21, Wnt3a, GSK-3β	Inhibiting proliferation, invasion, and migration; inducing apoptosis	[51, 52]
Hydroxysafflor yellow A	β-Catenin, MMP7, survivin, menin	Inhibiting proliferation; inducing apoptosis	[53]
Emodin	E-cadherin, keratin, vimentin, N-cadherin, MMP2, MMP9, p-GSK-3β, β-catenin, ZEBI	Inhibiting invasion; reversal of EMT	[54]
Oridonin	Vimentin, c-Myc, cyclin D1, E-cadherin, β-catenin	Inhibiting proliferation, invasion and migration; inducing apoptosis	[55]
Schisandrin B	β-Catenin, c-Myc, cyclin D1	Inducing apoptosis; blocking cell cycle progression	[56]
Apigenin	β-Catenin, E-cadherin	Inhibiting invasion and migration	[57, 58]
Camellia sinensis	p-AKT, p-GSK-3β, β-catenin, c-Myc, p-β-catenin	Inhibiting proliferation	[59, 60]
Icariin	β-Catenin, c-Myc, cyclin D1	Inhibiting proliferation	[61]
Epigallocatechin-3-gallate	β-Catenin, cyclin D1	Inducing apoptosis; blocking cell cycle progression	[62]
Paeonol	Bcl-2, Bax, β-catenin, c-Myc	Inhibiting proliferation and migration; inducing apoptosis; blocking cell cycle progression	[63, 64]
Tetrandrine	p-GSK3β, β-catenin, E-cadherin, N-cadherin, vimentin	Inhibiting proliferation, invasion, and migration; reversal of EMT	[65, 66]
Proanthocyanidins	β-Catenin, cyclin D1, c-Myc	Inhibiting proliferation; inducing apoptosis; blocking cell cycle progression; reversing transformation therapy resistance	[67]
Naringin	β-Catenin, cyclin D1, c-Myc	Inhibiting proliferation, invasion, and migration; reversing transformation therapy resistance	[68]