Research Article
The Analysis of bcl-2 in Association with p53 and Ki-67 in Triple Negative Breast Cancer and Other Molecular Subtypes in Ghana
Table 6
Association of p53 and Ki-67 with molecular subtypes and clinicopathologic characteristics.
| | p53 | | % Positive | Cramer’s V | Pearson’s Chi2 | Sig. () |
| | Molecular subtypes | | Luminal A | 41.4 | 0.021 | 0.070 | 0.791 | | Luminal B | 86.7 | 0.320 | 15.709 | <0.001 | | HER2 positive | 36.0 | 0.029 | 0.130 | 0.719 | | TNBC | 31.0 | 0.173 | 4.651 | 0.033 |
| | Clinicopathological characteristics | Histol. grade
I
II
III | 16.7
26.1
45.7 | 0.230 | 6.781 | 0.034 | | Lymphovascular invasion | 42.9 | 0.199 | 2.094 | 0.148 |
| | Ki-67 |
| | Molecular subtypes | | Luminal A | M 24.5
L 28.6 | 0.265 | 11.322 | <0.01 | | Luminal B | H 3.1
M 3.6
L 34.3 | 0.429 | 29.628 | <0.001 | | HER2 positive | H 13.3
M 32.1
L 11.4 | 0.200 | 6.467 | <0.05 | | TNBC | 66.7 | 0.168 | 4.595 | 0.101 |
| | Clinicopathological characteristics | | Histol. grade | | I | L 76.9
M 15.4
H 7.7 | 0.111 | 3.274 | 0.51 | | II | L 66.7
M 14.6
H 18.8 | | III | L 56.3
M 16.9
H 26.8 | | Lymphovascular invasion | L 59.3
M 22.2
H 18.5 | 0.129 | 0.912 | 0.634 | | Association between p53 and Ki-67 |
| | p53 | | Ki-67 low (mild) | 59.5 | 0.268 | 11.957 | <0.01 | | Moderate | 41.4 | | High (severe) | 27.7 |
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