The Clinical Significance and Potential Molecular Mechanism of Upregulated CDC28 Protein Kinase Regulatory Subunit 1B in Osteosarcoma

Figure 9

Weighted correlation network analysis (WGCNA) and nonnegative matrix factorization (NMF) analysis was conducted to explore coexpression genes of CKS1B. (a) The function of soft threshold parameter with scale-free fitting index and average connectivity. (b) Clustering system tree diagram of the combined gene matrix calculated by average hierarchical linkage clustering. The color squares below the tree diagram meant the modules cut by the dynamic tree. (c) Cophenetic line chart and heatmap of clustering pointed out k = 3.

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