Research Article

In Hepatocellular Carcinoma, miRNA-296-3p Targets MSL2 and Suppresses Cell Proliferation and Invasion

Figure 3

miRNA-296-3p negatively regulates the migration and invasion of HCC cells. Huh-7 and HepG2 cells were treated with NC mimic and miRNA-296-3p mimic. (a) Wound healing assay. Representative pictures are shown at 0 and 48 h after the wound was made. (b) Transwell chamber assay. Representative pictures shows the effects of miRNA-296-3p on migration and invasion. (a, b) Bar graph showing the migrated distance and number of migrated or invaded Huh-7 and HepG2 cells. (c) Western blot was used to evaluate migration- and invasion-related proteins (Cox-2, MMP-2, and MMP-9). Values were mean ± SE, vs. control, n = 3 per group.
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