Upregulated Expression of CYBRD1 Predicts Poor Prognosis of Patients with Ovarian Cancer

Table 3

Correlation between overall survival and clinicopathologic characteristics in TCGA patients applied Cox regression and multivariate survival model after variable selection.

Characteristics	Total (N)	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
FIGO stage (stage III and stage IV versus stage I and stage II)	371	2.085 (0.925–4.699)	0.076	2.866 (0.696–11.791)	0.145
Primary therapy outcome (CR versus PD, SD, and PR)	304	4.280 (3.091–5.928)	<0.001	0.263 (0.185–0.374)	<0.001
Anatomic neoplasm subdivision (bilateral versus unilateral)	353	1.041 (0.768–1.410)	0.798
Venous invasion (yes versus no)	103	0.905 (0.487–1.683)	0.753
Lymphatic invasion (yes versus no)	147	1.422 (0.839–2.411)	0.191
Tumor residual (RD versus NRD)	332	2.302 (1.479–3.583)	<0.001	1.589 (0.950–2.657)	0.077
Age (>60 versus ≤60)	374	1.373 (1.059–1.780)	0.017	1.314 (0.957–1.805)	0.092
CYBRD1 (high versus low)	374	1.438 (1.107–1.868)	0.007	1.319 (0.964–1.804)	0.083