Clinicopathologic Characteristics and Outcomes of Simultaneous Multiple Primary Lung Cancer
Table 1
Baseline clinical characteristics.
Overall patients, N = 336
Same histological type, N = 297
Different histological types, N = 39
value
Demographics
Age, yrs
63 (56–70)
59 (52–65)
65 (62–69)
<0.001
Females
207 (61.6)
202 (68.0)
5 (12.8)
<0.001
BMI, kg/m2
22.9 (20.9–24.7)
22.8 (20.8–24.7)
23.8 (21.1–25.0)
0.315
Symptoms
No symptom
232 (69.0)
215 (72.4)
17 (43.6)
<0.001
Respiratory symptom
72 (21.4)
58 (19.5)
14 (35.8)
0.019
Pain
21 (6.3)
17 (5.7)
4 (10.3)
0.285
Both
11 (3.3)
7 (2.4)
4 (10.3)
0.028
Smoking history
88 (26.2)
50 (16.8)
31 (79.5)
<0.001
Lung function (%)
FEV1
102 (90–113)
104 (94–114)
89 (72–96)
<0.001
DLCO
100 (86–112)
102 (88–112)
85 (80–97)
<0.001
Laboratory test
LDH
158 (139–176)
158 (139–176)
155 (143–180)
0.617
dNLR
1.47 (1.17–1.84)
1.44 (1.14–1.82)
1.73 (1.38–1.99)
0.013
Neutrophile granulocyte, 109
3.16 (2.57–4.05)
3.11 (2.55–3.90)
4.02 (2.92–4.92)
0.002
Features of lesions
Number
0.085
2
246 (73.2)
211 (71.0)
35 (89.7)
3
57 (17.0)
53 (17.8)
4 (10.3)
4
20 (6.0)
20 (6.8)
0 (0)
>4
13 (3.9)
13 (4.4)
0 (0)
Largest nodule size
>2 cm
156 (46.4)
120 (40.4)
36 (92.3)
<0.001
>1 cm
294 (87.5)
255 (85.9)
39 (100)
0.008
Location
0.541
Ipsilateral
209 (62.2)
183 (61.6)
26 (66.7)
Bilateral
127 (37.8)
114 (38.4)
13 (33.3)
Values are n (%) or median (interquartile range). BMI = body mass index; DLCO = diffusing capacity for carbon monoxide; dNLR = derive neutrophil-to-lymphocyte radio; FEV1 = forced expiratory volume in 1 second; LDH = lactate dehydrogenase.
