Research Article
Clinicopathologic Characteristics and Outcomes of Simultaneous Multiple Primary Lung Cancer
| | | All patients, N = 336 | Same histological type, N = 297 | Different histological types, N = 39 | value |
| | EGFR | | | | | | Tested patients | 196 (58.3) | 180 (60.6) | 16 (41.0) | — | | Tested lesions | 291 | 268 | 23 | — | | EGFR+ | 181 (62.2) | 174 (64.9) | 7 (30.4) | 0.001 | | EGFR− | 110 (37.8) | 94 (35.1) | 16 (69.6) | — | | ALK | | | | | | Tested patient | 290 (86.3) | 257 (86.5) | 33 (84.6) | — | | Tested lesions | 450 | 403 | 47 | — | | ALK+ | 9 (2.0) | 8 (2.0) | 1 (2.1) | 0.947 | | ALK− | 441 (98.0) | 395 (98.0) | 46 (97.9) | — | | ROS1 | | | | | | Tested patient | 280 (83.3) | 248 (83.5) | 32 (82.1) | — | | Tested lesions | 433 | 387 | 46 | — | | ROS1+ | 49 (11.3) | 49 (12.7) | 0 (0) | 0.01 | | ROS1− | 231 (88.7) | 338 (87.3) | 46 (100) | — | | KRAS | | | | | | Tested patient | 35 (10.4) | 33 (11.1) | 2 (5.1) | — | | Tested lesions | 57 | 54 | 3 | — | | KRAS+ | 3 (5.3) | 3 (5.6) | 0 (0) | 0.675 | | KRAS− | 54 (94.7) | 51 (94.4) | 3 (100) | — | | PD-L1 | | | | | | Tested patient | 190 (56.5) | 172 (57.9) | 18 (46.2) | — | | Tested lesions | 285 | 259 | 26 | — | | PD-L1+ | 33 (11.6) | 25 (9.7) | 8 (30.8) | 0.004 | | PD-L1− | 252 (88.4) | 234 (90.3) | 18 (69.2) | — |
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ALK = anaplastic lymphoma kinase; EGFR = epidermal growth factor receptor; KRAS = Kirsten-rat sarcoma 2 viral oncogene homolog; PD-L1 = programmed cell death ligand 1; ROS1 = ROS proto-oncogene 1.
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