The Alterations and Potential Roles of MCMs in Breast Cancer

Table 1

The significant changes of MCM expression in transcription level between different types of breast cancer and normal breast tissues (Oncomine database).

	Type of breast cancer versus normal breast tissue reference invasive breast carcinoma	Fold change	value	T-test	Source and/or reference
MCM1	NA	NA	NA	NA	NA
	Medullary breast carcinoma	3.557	1.54E − 15	13.256	Curtis breast [29]
	Invasive ductal breast carcinoma	2.503	3.82E − 92	34.511	Curtis breast [29]
	Breast carcinoma	2.062	4.52E − 6	6.693	Curtis breast [29]
MCM2	Mixed lobular and ductal breast carcinoma	2.200	1.18E − 6	8.165	TCGA
	Invasive lobular breast carcinoma	2.120	1.06E − 12	8.432	TCGA
	Invasive ductal breast carcinoma	2.877	5.24E − 31	17.777	TCGA
	Invasive breast carcinoma	2.184	1.30E − 17	9.743	TCGA
	Fibroadenoma	2.311	0.016	3.904	Sorlie breast [3]
MCM3	Fibroadenoma	2.535	0.019	4.415	Sorlie breast 2 [30]
	Medullary breast carcinoma	2.101	1.62E − 11	9.579	Curtis breast [21]
	Ductal breast carcinoma	3.081	3.36E − 14	13.705	Perou breast [31]
	Lobular breast carcinoma	2.698	0.013	4.040	Perou breast [31]
	Invasive ductal breast carcinoma	3.192	3.89E − 48	22.602	TCGA
	Invasive breast carcinoma	2.814	9.54E − 26	12.992	TCGA
	Invasive ductal and lobular carcinoma	2.990	2.27E − 7	13.999	TCGA
MCM4	Invasive lobular breast carcinoma	2.048	1.02E − 13	9.018	TCGA
	Medullary breast carcinoma	3.126	1.96E − 13	11.226	Curtis breast [29]
	Invasive ductal breast carcinoma	2.412	1.58E − 85	32.416	Curtis breast [29]
	Invasive breast carcinoma	2.011	4.18E − 6	5.726	Curtis breast [29]
	Invasive breast carcinoma	2.199	5.37E − 6	9.490	Gluck breast [32]
	Ductal breast carcinoma	3.806	7.88E − 8	8.590	Richardson breast 2 [33]
MCM5	Medullary breast carcinoma	2.622	2.34E − 17	15.507	Curtis breast [29]
	Intraductal cribriform breast adenocarcinoma	2.082	2.53E − 4	5.919	TCGA
	Ductal breast carcinoma	3.149	8.27E − 9	8.698	Richardson breast 2 [33]
	Medullary breast carcinoma	2.551	1.26E − 12	10.679	Curtis breast [21]
MCM6	Invasive lobular breast carcinoma	3.692	0.009	2.828	Radvanyi breast [34]
	Invasive ductal breast carcinoma	3.329	0.012	2.737	Radvanyi breast [34]
	Invasive ductal breast carcinoma	2.358	0.007	3.143	Turashvili breast [35]
MCM7	Medullary breast carcinoma	2.196	2.81E − 12	9.248	Curtis breast [29]
MCM8	Ductal breast carcinoma	2.050	5.56E − 9	6.961	Richardson breast 2 [33]
MCM9	NA	NA	NA	NA	NA
	Male breast carcinoma	4.716	5.49E − 26	20.205	TCGA
	Invasive ductal breast carcinoma	4.774	1.21E − 45	21.470	TCGA
	Invasive breast carcinoma	4.381	2.51E − 21	11.417	TCGA
MCM10	Invasive lobular breast carcinoma	2.510	4.92E − 11	7.582	TCGA
	Ductal breast carcinoma	7.508	1.68E − 12	9.492	Richardson breast 2 [33]
	Invasive ductal breast carcinoma	2.077	2.99E − 92	29.777	Curtis breast [29]
	Medullary breast carcinoma	3.802	3.90E − 13	11.272	Curtis breast [29]

NA, not available; TCGA, the Cancer Genome Atlas.