circSLC30A7 Inhibits Hepatocellular Carcinoma Cell Proliferation via the miR-767-5p/FBXW7/NOTCH1 Axis

Figure 7

CircSLC30A7 plays role in HCC via regulating the NOTCH1 pathway. (a) Gene Set Enrichment Analysis (GSEA) showed that FBXW7 expression was positively correlated with GO_REGULATION_NOTCH_SIGNALING_PATHWAY. The protein expression levels of FBXW7, NOTCH1, Cyclin D1, and PCNA were detected by western blotting assay in Huh7 cell (b) and HepG2 (c). GAPDH as control. A: empty vector; B: oe-circSLC30A; C: oe-circSLC30A7 + miR--NC; D: oe-circSLC30A7 + miR767-5p-mimic; E: sh-control; F: sh-circSLC30A7; G: sh-circSLC30A7 + anti-miR-NC; H: sh-circSLC30A7 + anti-miR-767-5p.

(a)

(b)

(c)