ACE2 Is a Prognostic Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma: Implication for COVID-19

Table 2

Correlation analysis between ACE2 and gene biomarkers of immune cells in KIRC (TIMER).

Description	Biomarkers	None		Purity
		Cor.	value	Cor.	value
CD8+ T cell	CD8A	0.0.119	∗∗	0.107	∗
	CD8B	0.115	∗∗∗	0.099	∗
T cell (general)	CD3D	0.045	0.298	0.027	0.565
	CD3E	0.064	0.14	0.048	0.302
	CD2	0.09	∗	0.077	0.0985
B cell	CD19	−0.176	∗∗∗	−0.186	∗∗∗
	CD79A	−0.12	∗∗	−0.144	∗∗
Monocyte	CD86	0.126	∗∗	0.117	∗
	CD115 (CSF1R)	0.096	∗	0.092	∗
TAM	CCL2	0.0.266	∗∗∗	0.28	∗∗∗
	CD68	0.146	∗∗∗	0.097	∗
	IL10	0.006	0.885	−0.016	0.733
M1 macrophage	INOS (NOS2)	0.2	∗∗∗	0.18	∗∗∗
	IRF5	0.229	∗∗∗	0.208	∗∗∗
	COX2 (PTGS2)	−0.219	∗∗∗	−0.205	∗∗∗
M2 macrophage	CD163	0.066	0.128	0.04	0.396
	VSIG4	−0.027	0.538	−0.061	0.188
	MS4A4A	0.019	0.668	0.002	0.973
Neutrophil	CD66b (CEACAM8)	0.071	0.0996	0.053	0.255
	CD11b (ITGAM)	0.159	∗∗∗	0.147	∗∗∗
	CCR7	−0.004	0.932	−0.039	0.403
Natural killer cell	KIR2DL1	0.17	∗∗∗	0.136	∗∗
	KIR2DL3	0.139	∗∗	0.106	∗
	KIR2DL4	0.024	0.584	0.002	0.964
	KIR3DL1	0.206	∗∗∗	0.168	∗∗∗
	KIR3DL2	0.138	∗∗	0.106	∗
	KIR3DL3	0.029	0.508	0.017	0.712
	KIR2DS4	0.08	0.0634	0.058	0.217
Dendritic cell	HLA-DPB1	0.221	∗∗∗	0.193	∗∗∗
	HLA-DQB1	0.208	∗∗∗	0.185	∗∗∗
	HLA-DRA	0.257	∗∗∗	0.23	∗∗∗
	HLA-DPA1	0.264	∗∗∗	0.25	∗∗∗
	BDCA-1 (CD1C)	0.185	∗∗∗	0.175	∗∗∗
	BDCA-4 (NRP1)	0.218	∗∗∗	0.207	∗∗∗
	CD11c (ITGAX)	0.038	0.385	0.025	0.591
Th1	T-bet (TBX21)	0.093	∗	0.064	0.167
	STAT4	−0.002	0.956	−0.04	0.886
	STAT1	0.219	∗∗∗	0.208	∗∗∗
	IFN-g (IFNG)	0.053	0.22	0.034	0.461
	TNF-a (TNF)	0.062	0.152	0.043	0.358
Th2	GATA3	−0.212	∗∗∗	−0.165	∗∗∗
	STAT6	0.323	∗∗∗	0.31	∗∗∗
	STAT5A	0.139	∗∗	0.16	∗∗∗
	IL13	−0.059	0.17	−0.088	0.0588
Tfh	BCL6	−0.076	0.0793	−0.089	0.0570
	IL21	−0.072	0.0972	−0.09	0.0546
Th17	STAT3	0.237	∗∗∗	0.239	∗∗∗
	IL17A	−0.031	0.472	−0.029	0.532
Treg	FOXP3	−0.127	−0.143	∗∗	∗∗
	CCR8	0.04	0.361	0.028	0.552
	STAT5B	0.433	∗∗∗	0.417	∗∗∗
	TGFb (TGFB1)	−0.253	∗∗∗	−0.271	∗∗∗
T cell exhaustion	PD-1 (PDCD1)	0.036	0.404	0.016	0.733
	CTLA4	0.012	0.78	−0.004	0.925
	LAG3	0.017	0.694	0.009	0.855
	TIM-3 (HAVCR2)	0.355	∗∗∗	0.32	∗∗∗
	GZMB	−0.029	0.507	−0.066	0.157

P < 0.05; P < 0.01; P < 0.001.