Research Article
ACE2 Is a Prognostic Biomarker and Associated with Immune Infiltration in Kidney Renal Clear Cell Carcinoma: Implication for COVID-19
Table 2
Correlation analysis between ACE2 and gene biomarkers of immune cells in KIRC (TIMER).
| Description | Biomarkers | None | Purity | Cor. | value | Cor. | value |
| CD8+ T cell | CD8A | 0.0.119 | ∗∗ | 0.107 | ∗ | CD8B | 0.115 | ∗∗∗ | 0.099 | ∗ | T cell (general) | CD3D | 0.045 | 0.298 | 0.027 | 0.565 | CD3E | 0.064 | 0.14 | 0.048 | 0.302 | CD2 | 0.09 | ∗ | 0.077 | 0.0985 | B cell | CD19 | −0.176 | ∗∗∗ | −0.186 | ∗∗∗ | CD79A | −0.12 | ∗∗ | −0.144 | ∗∗ | Monocyte | CD86 | 0.126 | ∗∗ | 0.117 | ∗ | CD115 (CSF1R) | 0.096 | ∗ | 0.092 | ∗ | TAM | CCL2 | 0.0.266 | ∗∗∗ | 0.28 | ∗∗∗ | CD68 | 0.146 | ∗∗∗ | 0.097 | ∗ | IL10 | 0.006 | 0.885 | −0.016 | 0.733 | M1 macrophage | INOS (NOS2) | 0.2 | ∗∗∗ | 0.18 | ∗∗∗ | IRF5 | 0.229 | ∗∗∗ | 0.208 | ∗∗∗ | COX2 (PTGS2) | −0.219 | ∗∗∗ | −0.205 | ∗∗∗ | M2 macrophage | CD163 | 0.066 | 0.128 | 0.04 | 0.396 | VSIG4 | −0.027 | 0.538 | −0.061 | 0.188 | MS4A4A | 0.019 | 0.668 | 0.002 | 0.973 | Neutrophil | CD66b (CEACAM8) | 0.071 | 0.0996 | 0.053 | 0.255 | CD11b (ITGAM) | 0.159 | ∗∗∗ | 0.147 | ∗∗∗ | CCR7 | −0.004 | 0.932 | −0.039 | 0.403 | Natural killer cell | KIR2DL1 | 0.17 | ∗∗∗ | 0.136 | ∗∗ | KIR2DL3 | 0.139 | ∗∗ | 0.106 | ∗ | KIR2DL4 | 0.024 | 0.584 | 0.002 | 0.964 | KIR3DL1 | 0.206 | ∗∗∗ | 0.168 | ∗∗∗ | KIR3DL2 | 0.138 | ∗∗ | 0.106 | ∗ | KIR3DL3 | 0.029 | 0.508 | 0.017 | 0.712 | KIR2DS4 | 0.08 | 0.0634 | 0.058 | 0.217 | Dendritic cell | HLA-DPB1 | 0.221 | ∗∗∗ | 0.193 | ∗∗∗ | HLA-DQB1 | 0.208 | ∗∗∗ | 0.185 | ∗∗∗ | HLA-DRA | 0.257 | ∗∗∗ | 0.23 | ∗∗∗ | HLA-DPA1 | 0.264 | ∗∗∗ | 0.25 | ∗∗∗ | BDCA-1 (CD1C) | 0.185 | ∗∗∗ | 0.175 | ∗∗∗ | BDCA-4 (NRP1) | 0.218 | ∗∗∗ | 0.207 | ∗∗∗ | CD11c (ITGAX) | 0.038 | 0.385 | 0.025 | 0.591 | Th1 | T-bet (TBX21) | 0.093 | ∗ | 0.064 | 0.167 | STAT4 | −0.002 | 0.956 | −0.04 | 0.886 | STAT1 | 0.219 | ∗∗∗ | 0.208 | ∗∗∗ | IFN-g (IFNG) | 0.053 | 0.22 | 0.034 | 0.461 | TNF-a (TNF) | 0.062 | 0.152 | 0.043 | 0.358 | Th2 | GATA3 | −0.212 | ∗∗∗ | −0.165 | ∗∗∗ | STAT6 | 0.323 | ∗∗∗ | 0.31 | ∗∗∗ | STAT5A | 0.139 | ∗∗ | 0.16 | ∗∗∗ | IL13 | −0.059 | 0.17 | −0.088 | 0.0588 | Tfh | BCL6 | −0.076 | 0.0793 | −0.089 | 0.0570 | IL21 | −0.072 | 0.0972 | −0.09 | 0.0546 | Th17 | STAT3 | 0.237 | ∗∗∗ | 0.239 | ∗∗∗ | IL17A | −0.031 | 0.472 | −0.029 | 0.532 | Treg | FOXP3 | −0.127 | −0.143 | ∗∗ | ∗∗ | CCR8 | 0.04 | 0.361 | 0.028 | 0.552 | STAT5B | 0.433 | ∗∗∗ | 0.417 | ∗∗∗ | TGFb (TGFB1) | −0.253 | ∗∗∗ | −0.271 | ∗∗∗ | T cell exhaustion | PD-1 (PDCD1) | 0.036 | 0.404 | 0.016 | 0.733 | CTLA4 | 0.012 | 0.78 | −0.004 | 0.925 | LAG3 | 0.017 | 0.694 | 0.009 | 0.855 | TIM-3 (HAVCR2) | 0.355 | ∗∗∗ | 0.32 | ∗∗∗ | GZMB | −0.029 | 0.507 | −0.066 | 0.157 |
|
|
P < 0.05; P < 0.01; P < 0.001. |