Research Article
Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC
Table 2
Differently expressed genes from GSE84957.
| | GeneSample | logFC | AveExpr | t | value | Adj. value | B |
| | CST1 | 4.255518022 | 7.417759878 | 14.09776157 | 1.49E − 11 | 3.71E − 07 | 15.51198443 | | XLOC_004426 | 3.044228211 | 3.370726783 | 11.59258332 | 4.32E − 10 | 3.61E − 06 | 12.75595229 | | MMP11 | 3.903325333 | 6.986877144 | 11.58573097 | 4.36E − 10 | 3.61E − 06 | 12.74750381 | | GPRIN1 | 3.857745044 | 5.653573411 | 11.29565743 | 6.67E − 10 | 4.15E − 06 | 12.38486185 | | COL7A1 | 3.191737644 | 9.258242733 | 10.78042002 | 1.45E − 09 | 7.22E − 06 | 11.71597451 | | FAM3D | −5.792545067 | 7.2950313 | −10.09792 | 4.24E − 09 | 1.51E − 05 | 10.77877059 | | LRP12 | 3.580821556 | 4.005304867 | 9.316160682 | 1.54E − 08 | 4.26E − 05 | 9.629111691 | | CTHRC1 | 4.740806433 | 7.128087172 | 9.196467428 | 1.89E − 08 | 4.30E − 05 | 9.445581444 | | LOC100506027 | 4.143287578 | 4.568671189 | 8.999347488 | 2.66E − 08 | 4.97E − 05 | 9.138857621 | | TJP3 | −3.364634633 | 7.834813517 | −8.904023211 | 3.14E − 08 | 4.97E − 05 | 8.9885142 | | IGFBP3 | 3.604138167 | 10.55244692 | 8.893742313 | 3.20E − 08 | 4.97E − 05 | 8.972220302 | | ARSI | 3.152646867 | 3.986923189 | 8.298478812 | 9.26E − 08 | 0.000121313 | 8.002153147 | | TMEM158 | 3.718106033 | 4.697089117 | 8.222894187 | 1.06E − 07 | 0.000132353 | 7.875178695 | | PLAUR | 3.027472033 | 7.824632761 | 8.051498015 | 1.46E − 07 | 0.000165132 | 7.584034636 | | MSR1 | 3.918547922 | 4.497970906 | 7.705672 | 2.80E − 07 | 0.000248682 | 6.98290287 | | TGFBI | 3.415596633 | 9.235072794 | 7.534242043 | 3.89E − 07 | 0.000311941 | 6.678084284 | | SPP1 | 4.853097222 | 7.318721011 | 7.296283387 | 6.17E − 07 | 0.000415016 | 6.247440183 | | CYP4B1 | −3.938406289 | 5.174530178 | −7.145413133 | 8.31E − 07 | 0.000492716 | 5.96986977 | | SH3BGRL2 | −4.071528089 | 6.438326422 | −7.12999436 | 8.57E − 07 | 0.000495582 | 5.941304558 | | LOC100653149 | 3.268119356 | 5.443807811 | 7.078046014 | 9.50E − 07 | 0.000525005 | 5.844794163 | | MMP1 | 4.862459922 | 6.783056994 | 7.002232691 | 1.10E − 06 | 0.000590601 | 5.70320204 | | TM4SF19 | 4.052795678 | 5.81647465 | 6.87435807 | 1.43E − 06 | 0.000696569 | 5.462380919 | | COL5A2 | 3.504323078 | 7.584409283 | 6.759032897 | 1.80E − 06 | 0.000815742 | 5.243053839 | | HOXD11 | 3.550990856 | 5.087563172 | 6.54672159 | 2.78E − 06 | 0.001117349 | 4.834020589 | | CXCL11 | 4.762321211 | 4.652769394 | 6.519758265 | 2.94E − 06 | 0.00115171 | 4.781590785 | | LOC100652832 | 3.253860656 | 6.465006439 | 6.502526246 | 3.05E − 06 | 0.00115171 | 4.748026804 | | CXCL10 | 4.519192844 | 5.640273644 | 6.498769364 | 3.07E − 06 | 0.00115171 | 4.740703422 | | XLOC_006053 | −3.635899633 | 9.156396294 | −6.475756406 | 3.22E − 06 | 0.00115171 | 4.69579809 | | KRT17 | 4.404712111 | 11.51599561 | 6.464235069 | 3.30E − 06 | 0.00115171 | 4.673287016 | | PTHLH | 4.098820033 | 7.949679894 | 6.341212465 | 4.26E − 06 | 0.001315184 | 4.431701824 | | CXCL12 | −3.476515767 | 8.330393117 | −6.24092991 | 5.26E − 06 | 0.001422596 | 4.233143024 | | XLOC_l2_006021 | 4.372459256 | 11.50269782 | 6.229963809 | 5.38E − 06 | 0.001424781 | 4.211342414 | | COL8A1 | 3.211121667 | 6.060922078 | 6.177430972 | 6.01E − 06 | 0.001526438 | 4.106669064 | | CLCA4 | −5.919341656 | 8.217143061 | −6.126082361 | 6.70E − 06 | 0.001661254 | 4.003977039 | | HMGA2 | 3.706329122 | 3.703429261 | 6.117033971 | 6.83E − 06 | 0.00166615 | 3.985842669 | | WISP1 | 3.021981556 | 5.595450789 | 6.039266244 | 8.06E − 06 | 0.001838778 | 3.829512486 | | NRG1 | 3.430506311 | 6.615773067 | 6.013403137 | 8.51E − 06 | 0.001907796 | 3.777336092 | | ANKRD20A9P | −3.027104311 | 6.964110233 | −5.991259577 | 8.92E − 06 | 0.001947336 | 3.732590438 | | GCNT3 | −3.483360222 | 5.808183467 | −5.968076797 | 9.38E − 06 | 0.001965485 | 3.685672938 | | MYOC | −3.290936644 | 3.378123278 | −5.964261662 | 9.45E − 06 | 0.001965485 | 3.677944815 | | ODZ2 | 3.030850211 | 7.342800339 | 5.955698768 | 9.63E − 06 | 0.001965485 | 3.660592194 | | DNAPTP3 | 4.162512589 | 8.355008817 | 5.948057503 | 9.79E − 06 | 0.001979224 | 3.645098841 | | FUT3 | −3.452809133 | 7.136305 | −5.832221646 | 1.25E − 05 | 0.00221345 | 3.409270286 | | CRNN | −6.524733278 | 9.72241585 | −5.821941297 | 1.28E − 05 | 0.002227034 | 3.388254529 | | CFD | −3.520037456 | 9.369048272 | −5.800510125 | 1.34E − 05 | 0.002286888 | 3.344398953 | | COL1A2 | 3.096446333 | 11.78684306 | 5.800402532 | 1.34E − 05 | 0.002286888 | 3.34417863 | | CXCL9 | 3.067348622 | 6.615663178 | 5.759709415 | 1.47E − 05 | 0.002369549 | 3.260741185 | | PDPN | 3.170275733 | 10.0438188 | 5.709284988 | 1.64E − 05 | 0.00252911 | 3.157054467 | | INHBA | 3.099887078 | 5.809753317 | 5.656043661 | 1.84E − 05 | 0.002640463 | 3.04722486 | | MMP12 | 4.162521167 | 3.736549417 | 5.638864584 | 1.91E − 05 | 0.002687547 | 3.011710913 | | SCARA5 | −3.861003467 | 7.106386856 | −5.634806253 | 1.92E − 05 | 0.002687547 | 3.003315853 | | COL4A1 | 3.293993722 | 11.03886292 | 5.623430739 | 1.97E − 05 | 0.002709232 | 2.979773593 | | COL5A1 | 3.205179622 | 8.674301744 | 5.604407653 | 2.05E − 05 | 0.00279295 | 2.940368581 | | ANKRD20A5P | −3.118826611 | 5.357065783 | −5.574210889 | 2.19E − 05 | 0.002873117 | 2.877727019 | | TNXB | −3.390147544 | 8.386793894 | −5.46437267 | 2.79E − 05 | 0.003345526 | 2.648949986 | | CCDC25 | −3.340572133 | 7.218539933 | −5.461095079 | 2.81E − 05 | 0.003345526 | 2.6421014 | | FN1 | 3.580535444 | 11.63254756 | 5.427958008 | 3.02E − 05 | 0.003525959 | 2.572791248 | | MAL | −6.360331133 | 8.9132381 | −5.380498508 | 3.36E − 05 | 0.003726774 | 2.473306046 | | FBN2 | 3.702098767 | 4.647001128 | 5.317540391 | 3.86E − 05 | 0.003963698 | 2.340945176 | | KRT4 | −5.783585056 | 12.44990214 | −5.27501498 | 4.24E − 05 | 0.004304541 | 2.251297748 | | MSC | 3.021481811 | 5.778950494 | 5.273063535 | 4.25E − 05 | 0.004304541 | 2.247179302 | | MYZAP | −3.966621 | 6.975986556 | −5.218924365 | 4.80E − 05 | 0.00453758 | 2.132761995 | | CHI3L1 | 3.447755856 | 8.454925183 | 5.212706409 | 4.86E − 05 | 0.004565936 | 2.119601631 | | XLOC_008370 | −4.086801056 | 5.071876417 | −5.195774385 | 5.05E − 05 | 0.004618685 | 2.083744902 | | AMY1C | −3.066162922 | 4.171807861 | −5.181124682 | 5.22E − 05 | 0.004702673 | 2.052698071 | | FAM107 A | −3.366929044 | 6.613174211 | −5.153177492 | 5.55E − 05 | 0.004829406 | 1.993410827 | | CA9 | 4.004719489 | 4.832498267 | 5.105740988 | 6.17E − 05 | 0.005199505 | 1.89260426 | | SFI1 | −3.172654489 | 7.898643289 | −5.038975245 | 7.16E − 05 | 0.005657681 | 1.75036129 | | KRT24 | −4.307497756 | 6.663276378 | −4.903497209 | 9.71E − 05 | 0.006802832 | 1.460515802 | | FAM3B | −3.002864178 | 7.472917967 | −4.851035631 | 0.000109236 | 0.007385034 | 1.347873623 | | PSCA | −4.424161267 | 6.177034822 | −4.836697273 | 0.000112824 | 0.007525305 | 1.317050516 | | TREM1 | 3.132156567 | 5.329140306 | 4.802412753 | 0.000121894 | 0.007755997 | 1.243287728 | | MMP7 | 4.0077695 | 8.433879583 | 4.797447382 | 0.000123267 | 0.007808567 | 1.232597743 | | XLOC_l2_007931 | −3.335940244 | 10.48608082 | −4.789159173 | 0.000125595 | 0.007875182 | 1.214750103 | | KRT6B | 4.076616322 | 9.703940506 | 4.773184049 | 0.000130209 | 0.007978995 | 1.180336064 | | SERPINE1 | 3.5038576 | 7.4466057 | 4.752919626 | 0.00013631 | 0.008152053 | 1.136656679 | | ABCA8 | −3.2918408 | 5.542601178 | −4.749840302 | 0.000137262 | 0.008169717 | 1.130016856 | | SNX31 | −3.294362333 | 3.714450967 | −4.727065435 | 0.000144517 | 0.008363625 | 1.080888859 | | KRT16 | 3.956891967 | 10.74006252 | 4.71119429 | 0.000149801 | 0.008567571 | 1.046633089 | | RSAD2 | 3.410952911 | 5.3110705 | 4.667343136 | 0.000165442 | 0.009086152 | 0.951904596 | | CEACAM5 | −3.982757711 | 9.060092478 | −4.649201732 | 0.000172387 | 0.009343839 | 0.912681384 |
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