Network Pharmacology and Bioinformatics Methods Reveal the Mechanism of Zao-Jiao-Ci in the Treatment of LSCC

Table 3

The topological properties of the 60 key nodes.

Name (the key targets)	Degree	Betweenness	Betweenness centrality	Closeness	Closeness centrality	Topological coefficient
YWHAZ	155	3001.377571	0.01183919	0.585365854	0.58536585	0.14373835
YWHAG	87	816.3912445	0.00322033	0.537313433	0.53731343	0.16424877
MCM5	101	1080.133008	0.00426068	0.542518837	0.54251884	0.14457089
STAU1	114	1407.485881	0.00555195	0.550218341	0.55021834	0.13468492
ITGA4	208	7021.25165	0.02769593	0.616891065	0.61689106	0.10712371
APP	125	5666.777349	0.02235309	0.557522124	0.55752212	0.10929128
CUL3	211	7900.538977	0.03116436	0.626865672	0.62686567	0.1083315
CUL2	121	2193.490854	0.00865241	0.556906077	0.55690608	0.1311238
CUL4A	84	1104.388869	0.00435636	0.519052523	0.51905252	0.14961657
CUL1	158	2737.270054	0.0107974	0.579976985	0.57997699	0.12774443
COPS5	173	4596.081368	0.01812964	0.592941176	0.59294118	0.11812865
YWHAQ	116	2340.92677	0.00923399	0.5532382	0.5532382	0.13955671
EEF1A1	111	2303.865101	0.0090878	0.553846154	0.55384615	0.15726594
OBSL1	151	2614.051749	0.01031135	0.572077185	0.57207719	0.11367624
TARDBP	99	902.4212542	0.00355968	0.540192926	0.54019293	0.14812918
HSPA8	102	1110.484051	0.0043804	0.549019608	0.54901961	0.1617004
HSPA5	124	2786.82878	0.01099289	0.56187291	0.56187291	0.15308876
HSP90AA1	115	3058.241745	0.0120635	0.558139535	0.55813953	0.13921995
EIF4A3	94	923.5252369	0.00364293	0.535031847	0.53503185	0.14405585
HSP90AB1	111	2024.466508	0.00798568	0.555066079	0.55506608	0.14751182
MYC	88	1227.898615	0.00484355	0.536741214	0.53674121	0.11599255
CCDC8	145	2628.810161	0.01036957	0.568848758	0.56884876	0.11392955
HDAC1	84	1756.679856	0.00692938	0.525547445	0.52554745	0.11154264
RPA1	106	1443.910092	0.00569563	0.544864865	0.54486486	0.13668578
RPA2	98	1508.905701	0.00595201	0.541353383	0.54135338	0.13008096
HNRNPA1	130	1803.567503	0.00711433	0.565656566	0.56565657	0.14709052
EGFR	143	4724.066642	0.01863449	0.572727273	0.57272727	0.1103327
HIST1H3F	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
UBC	133	3538.655204	0.01395853	0.566929134	0.56692913	0.12972445
CUL7	174	4304.231567	0.01697841	0.594339623	0.59433962	0.10695547
HNRNPK	90	914.3729176	0.00360682	0.535600425	0.53560043	0.17748918
TUBB	85	1017.885462	0.00401514	0.537886873	0.53788687	0.16372149
HNRNPU	106	2391.698718	0.00943426	0.547826087	0.54782609	0.15722622
CDK2	172	5391.386868	0.02126679	0.592941176	0.59294118	0.11382953
EWSR1	85	1514.316862	0.00597335	0.532206969	0.53220697	0.15183716
CDC5L	113	2162.954989	0.00853196	0.550819672	0.55081967	0.13024984
NEDD8	86	533.4516789	0.00210425	0.528301887	0.52830189	0.14769424
HIST1H3A	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
HIST1H3D	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
TRAF6	100	2757.045931	0.01087541	0.538461538	0.53846154	0.09652163
HIST1H3C	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
NPM1	156	3506.462925	0.01383155	0.58400927	0.58400927	0.14115178
HIST1H3E	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
HIST1H3I	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
HIST1H3G	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
FUS	109	1065.023899	0.00420108	0.551422319	0.55142232	0.157963
HIST1H3J	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
HIST1H3H	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
HIST1H3B	86	437.5273205	0.00172586	0.529411765	0.52941176	0.14705882
NTRK1	270	16394.02825	0.06466766	0.673796791	0.67379679	0.09989618
FLNA	89	1820.058448	0.00717938	0.537313433	0.53731343	0.15216314
FN1	307	27515.32665	0.10853658	0.708860759	0.70886076	0.09048518
SIRT7	128	2444.801055	0.00964373	0.5532382	0.5532382	0.11177503
GRB2	136	4533.847683	0.01788415	0.570135747	0.57013575	0.12538522
FBXO6	129	2240.28371	0.00883699	0.558139535	0.55813953	0.11844315
VCP	103	1651.524516	0.00651458	0.544864865	0.54486486	0.14998166
CAND1	152	2355.429527	0.0092912	0.578645235	0.57864524	0.12845528
XPO1	106	2782.081388	0.01097416	0.543103448	0.54310345	0.12465874
MCM2	207	6633.522707	0.0261665	0.621454994	0.62145499	0.11887293
YWHAE	93	1174.476977	0.00463283	0.537313433	0.53731343	0.16260551