BCL-2 (-938C>A), BAX (-248G>A), and HER2 Ile655Val Polymorphisms and Breast Cancer Risk in Indian Population
Table 4
Genotype distribution, allele frequency, and association analysis of HER2 Ile655Val polymorphism and risk of breast cancer under different genetic models.
Genotype/allele
Cases (n = 117)
Control (n = 104)
Odd ratio (95% CI)
value
Ile(A)/Ile(A)
65 (55.55%)
79 (75.96%)
Ref
Ref
Ile(A)/Val(G)
44 (37.60%)
22 (21.15%)
2.43 (1.32–4.46)
0.004∗
Val(G)/Val(G)
8 (6.83%)
3 (2.88%)
3.24 (0.82–12.7)
0.091
value 0.0059
Recessive model
GG
8
3
2.47 (0.63–9.57)
0.190
AG + AA
109
101
Dominant model
AG + GG
52
25
2.52 (1.41–4.51)
0.001
AA
65
79
Codominant model
AG
44
22
2.24 (1.23–4.09)
0.008
AA + GG
73
82
Allele
Ile (A)
174 (74.36%)
180 (86.54%)
2.21 (1.35–3.63)
0.0016
Val (G)
60 (25.64%)
28 (13.46%)
n: number of samples, OR: odds ratio, and CI: confidence interval. Significant at < 0.05.
