Surgical Disparities of Parathyroid Carcinoma: Long-Term Outcomes and Deep Excavation Based on a Large Database

Table 6

Multivariate analyses results for clinicopathologic parameters associated with the cancer-specific survival and overall survival focusing on parathyroidectomy and en bloc radical resection in a different extent of resection.

Covariate	Level	HR	CSS		value	HR	OS		value
			95% CI				95% CI
Age at diagnosis	<45	Ref.				Ref.
	45–59	1.857	0.376	9.164	0.447	1.507	0.773	2.939	0.229
	60–69	4.453	0.842	23.557	0.079	3.138	1.538	6.401	0.002
	70–79	3.951	0.715	21.815	0.115	3.526	1.711	7.265	0.001
	>80	—	—	—	—	7.787	2.642	22.952	<0.001
Year of diagnosis	1973–2004	Ref.				Ref.
	2004–2015	0.336	0.109	1.031	0.057	0.68	0.409	1.129	0.136
Sex	Female	Ref.				Ref.
	Male	0.483	0.186	1.254	0.135	0.644	0.425	0.978	0.039
Race	White	Ref.				Ref.
	Black	2.396	0.81	7.089	0.114	2.125	1.289	3.503	0.003
	Other	0.894	0.115	6.97	0.915	1.28	0.608	2.692	0.515
Extent of diseases	Local disease	Ref.				Ref.
	Regional disease	1.877	0.453	7.779	0.385	1.357	0.705	2.611	0.361
	Metastatic disease	7.415	0.745	73.743	0.087	6.42	2.08	19.815	0.001
Radiation	No	Ref.				Ref.
	Yes	1.034	0.23	4.646	0.965	1.74	0.948	3.193	0.074
Extent of resection	Parathyroidectomy	Ref.				Ref.
	En bloc radical resection	1.183	0.261	5.367	0.827	1.225	0.62	2.421	0.56