Nomograms for Predicting Prognosis of Primary Mediastinal Seminoma: A Population-Based Study

Table 1

Clinical characteristics of patients with primary mediastinal seminoma in the primary cohort, training cohort, and validation cohort.

Variable	Primary cohort (n = 476)		Training cohort (n = 333)		Validation cohort (n = 143)		value
	Number	%	Number	%	Number	%
Sex							1.000
Male	462	97.1	323	97.0	139	97.2
Female	14	2.9	10	3.0	4	2.8
Age (years)							0.495
<20	47	9.9	30	9.0	17	11.9
20∼40	299	62.8	209	62.8	90	62.9
40∼60	112	23.5	79	23.7	33	23.1
≥60	18	3.8	15	4.5	3	2.1
Year of diagnosis							0.316
<2004	213	44.7	154	46.2	59	41.3
≥2004	263	55.3	179	53.8	84	58.7
Race							0.438
White	387	81.3	268	80.5	119	83.2
Black	42	8.8	33	9.9	9	6.3
Other	47	9.9	32	9.6	15	10.5
Marital status							0.285
Single	245	51.5	164	49.2	81	56.6
Married	188	39.5	136	40.8	52	36.4
Other	43	9.0	33	9.9	10	7.0
Extent of disease							0.702
Localized	155	32.6	107	32.1	48	33.6
Regional	134	28.1	99	29.7	35	24.5
Distant	131	27.5	89	26.7	42	29.4
Unknown	56	11.8	38	11.4	18	12.6
Extent of primary site							0.986
CSO	101	21.2	70	21.0	31	21.7
LNOS	92	19.3	64	19.2	28	19.6
ACT	28	5.9	20	6.0	8	5.6
AO/S	106	22.3	74	22.2	32	22.4
FCE	22	4.6	17	5.1	5	3.5
Unknown	127	26.7	88	26.4	39	27.3
Lymph nodes involved							0.606
Yes	107	22.5	79	23.7	28	19.6
No	268	56.3	185	55.6	83	58.0
Unknown	101	21.2	69	20.7	32	22.4
Metastasis							0.770
Yes	131	27.5	89	26.7	42	29.4
No	288	60.5	205	61.6	83	58.0
Unknown	57	12.0	39	11.7	18	12.6
Size of tumor (cm)							0.383
<10	101	21.2	65	19.5	36	25.2
≥10	201	42.2	144	43.2	57	39.9
Unknown	174	36.6	124	37.2	50	35.0
Surgery							0.036
Performed	113	23.7	88	26.4	25	17.5
NP/NA	363	76.3	245	73.6	118	82.5
Radiation							0.574
Performed	94	19.7	68	20.4	26	18.2
NP/NA	382	80.3	265	79.6	117	81.8
Chemotherapy							0.836
Performed	407	85.5	284	85.3	123	86.0
NP/NA	69	14.5	49	14.7	20	14.0

CSO, confined to site of origin; LNOS, localized (not of specified); ACT, extend to adjacent connective tissue; AO/S, adjacent organs/structures; FCE, further contiguous extension; NP/NA, not performed or unknown. : Asian or Pacific Islander, American Indian/Alaska native, unknown. : divorced, separated, widowed, and unknown. : beam radiation and radiation (not otherwise specified method or source not specified).