Immune Score Predicts Outcomes of Gastric Cancer Patients Treated with Adjuvant Chemoradiotherapy

Table 2

Univariate and multivariate Cox regression analysis for disease-free survival.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Sex (F/M)	0.796 (0.452, 1.402)	0.430	—	—
Age (≥65/<65)	1.641 (0.868, 3.099)	0.127	—	—
ECOG (1/0)	1.221 (0724, 2.060)	0.454	—	—
LDH(≥250/<250 U/L)	0.864 (0.311, 2.395)	0.778	—	—
CEA(≥5/<5 ng/ml)	3.002 (1.331, 6.863)	0.008	2.491 (0.942, 6.585)	0.066
Tumor location		0.266	—	—
Upper 1/3	reference
Middle 1/3	1.581 (0.671, 3.729)	0.295
Lower 1/3	0.928 (0.467, 1.843)	0.831
Total stomach	1.953 (0.676, 5.643)	0.216
Surgery type (total/subtotal)	2.332 (1.378, 3.946)	0.002	1.429 (0.760, 2.690)	0.268
Size (≥5/<5 cm)	1.597 (0.953, 2.676)	0.076	0.835 (0.468, 1.489)	0.542
Grade (poor/moderate)	2.1 (1.147, 3.846)	0.014	1.055(0.505, 2.203)	0.886
Borrmann classification		0.071		0.151
I	<0.001	0.977	<0.001	0.977
II	0.278 (0.108, 0.719)	0.008	0.212 (0.055, 0.819)	0.024
III	0.567 (0.291, 1.107)	0.096	0.548 (0.263, 1.140)	0.108
IV	reference		reference
pTNM(III/II)	4.720 (1.879, 11.859)	0.001	3.381 (1.156, 9.891)	0.026
LVI (+/−)	1.266 (0.731, 2.194)	0.399		—
PNI (+/−)	1.490 (0.860, 2.582)	0.155		—
IS		<0.001		<0.001
Low	reference		reference
Intermediate	0.269 (0.144, 0.500)	<0.001	0.338 (0.163,0.703)	0.004
High	0.067 (0.024, 0.188)	<0.001	0.124 (0.041, 0.375)	<0.001

Values in bold indicate < 0.05. CI, confidence interval; HR, hazard ratio; F/M, female/male; LVI, lymphatic and vascular invasion; PNI, perineural invasion.