Nrf3 Promotes 5-FU Resistance in Colorectal Cancer Cells via the NF-κB/BCL-2 Signaling Pathway In Vitro and In Vivo

Figure 3

Nrf3 is involved in the cell cycle. HT29, HT29/Nrf3, SW620, and SW620/shNrf3 were treated with different concentrations of 5-FU for 24 h. The cell cycle was determined by flow cytometry. (a) Representative images of the cell cycle. (b, c, d, e). The proportions of cells in each cell cycle phase. These results showed that Nrf3 decreased 5-FU-induced G0/G1-phase cell cycle arrest.

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