Research Article
Nrf3 Promotes 5-FU Resistance in Colorectal Cancer Cells via the NF-κB/BCL-2 Signaling Pathway In Vitro and In Vivo
Table 2
Correlation between Nrf3 expression and clinicopathologic factors.
| Variables | Cases | NRF3 | | + | − |
| Age | | | | 0.294 | <60 | 40 | 21 | 19 | ≥60 | 57 | 36 | 21 |
| Sex | | | | 0.501 | Male | 62 | 38 | 24 | Female | 35 | 19 | 16 |
| Smoke | | | | 0.178 | + | 36 | 18 | 18 | − | 61 | 39 | 22 |
| Tumor differentiation | | | | 0.675 | Low | 13 | 8 | 5 | Median | 55 | 28 | 27 | High | 29 | 21 | 8 |
| TNM classification | | | | 0.798 | I | 5 | 2 | 3 | II | 48 | 29 | 19 | III | 30 | 17 | 13 | IV | 14 | 9 | 5 |
| Lymph node metastasis | | | | 0.528 | + | 40 | 22 | 18 | − | 57 | 35 | 22 |
| Distant metastasis | | | | 0.873 | + | 14 | 9 | 5 | − | 83 | 48 | 35 |
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