Research Article

Dairy Consumption and Risk of Conventional and Serrated Precursors of Colorectal Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Table 1

Characteristic of the 3 cohort studies included in the meta-analysis investigating the effect of dairy consumption on the risk of precursors of CRC.

Author/year/countryStudy characteristicsAge and sexNumber of casesNumber of controlsDietary assessmentsExposureContrast (highest vs. lowest)OR/RR (95% CI)Adjustments

Kampman et al./1994/USAUndergone a sigmoidoscopy or colonoscopy within the follow-up period (HPFS, 1986–1990: 9490 men; NHS, 1980–1988: 8925 women)HPFS: 40–75 years, men
NHS: 30–55 years, women
331 men and 350 women with adenomatous polyps of the left colon or rectum9159 men and 8585 women with endoscopic findings negative for adenomaValidated FFQMilk (whole)C5 vs. C1Age, total energy, family history, and saturated fat intake
HPFS0.75 (0.29–1.91)
NHS1.35 (0.76–2.41)
Milk (skim/lowfat)C5 cs C1
HPFS1.06 (0.72–1.54)
NHS0.91 (0.63–1.30)
Fermented dairy productsC5 vs. C1
HPFS1.06 (0.72–1.57)
NHS0.89 (0.63–1.25)
Hard cheeseC4 vs. C1
HPFS1.28 (0.88–1.86)
C5 vs. C1
NHS0.81 (0.40–1.67)

Kesse et al./2005/FranceE3N-EPIC: 1933 women who had reported diagnosis of a colorectal polyp between the return of the dietary questionnaire (10993–1995) and the endpoint of the analysis (December 1997)40–65 years, women516 women with adenoma4804 polyp-free womenValidated FFQ-208Total dairy products>424.29 g/d vs. <184.83 g/d0.80 (0.62–1.05)Educational lever, current smoking status, family history of colon cancer, body mass index, physical activity level and energy and alcohol intake
Milk0.93 (0.73–1.19)
Yogurt0.87 (0.68–1.13)
Cottage cheese1.01 (0.80–1.29)
Cheese0.90 (0.69–1.17)

Zheng et al./2020/USAHPFS: 32606 men NHS: 55743 women undergone lower endoscopy between 1986 and 2012.NA, M + F5811 adenomas in men and 8116 adenomas in women26795 men and 47627 women with endoscopic findings negative for adenomaValidated FFQYogurtHPFS≧2/week vs. neverConventional adenomas 0.81 (0.71–0.94)Age, time period of endoscopy, number of reported endoscopies, time since most recent endoscopy and reason for current endoscopy, height, body mass index, family history of CRC, diabetes, pack-years of smoking, alcohol intake, physical activity in METs, regular use of aspirin, regular NSAIDs use, total vitamin D intake, nonyogurt dairy intake, total calorie intake, red and processed meat intake, dietary fiber intake, total folate intake, alternative healthy eating Index-2010, total calcium intake, menopausal status, and menopausal hormone use.
Serrated lesion 0.89 (0.74–1.07)
Conventional adenomas and serrated lesions 0.78 (0.59–1.04)
NHS ≧2/week vs. neverConventional adenomas 0.98 (0.88–1.09)
Serrated lesion 0.92 (0.82–1.04)
Conventional adenomas and serrated lesions 0.94 (0.76–1.17)

HPFS: Health Professionals Follow-Up Study; NHS: Nurses’ Health Study; FFQ: Food Frequency Questionnaire; RR: relative risk; OR: odds ratio; NA: not available; C5 vs. C1: frequency of consumption of one 8-ounce glass; C1, almost never; C5, more than once per day.