Research Article

Dairy Consumption and Risk of Conventional and Serrated Precursors of Colorectal Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Table 2

Characteristic of the 9 case-control studies included in the meta-analysis investigating the effect of dairy consumption on the risk of precursors of CRC.

Author/year/countryAge and sexNumber of casesNumber of controlsDietary assessmentsExposureContrast (highest vs. lowest)OR (95% CI)Adjustments

Boutron et al./1996/FrenchAged 30–75, M + F154 small adenomas (<10 mm)426 polyp-freeValidated FFQTotal milkQ5 vs. Q11.1 (0.6–1.9)Age, sex, and caloric intake
Low-fat milk1.0 (0.5–1.7)
Hard and semihard cheese1.2 (0.6–2.4)
Cottage cheeseQ3 vs. Q11.0 (0.7–1.6)
Yogurt1.3 (0.8–2.2)
208 large adenomas (>10 mm)154 small adenomas (<10 mm)Total milkQ5 vs. Q11.0 (0.5–2.0)
Low-fat milk1.1 (0.5–2.1)
Hard and semihard cheese1.1 (0.5–2.5)
Cottage cheeseQ3 vs. Q11.1 (0.7–1.8)
Yogurt0.5 (0.3–0.9)

Diergaarde et al./2005/DutchAged 18–75, M + F278 CRA414 polyp-freeValidated FFQ-178Dairy products≧495.0 g/d vs. ≦238.9 g/d0.7 (0.4–1.0)Age, gender, and total energy intake

Nasab et al./2020/IranCases: aged 56.46 ± 10.01, controls: aged 55.08 ± 9.45, M + F139 CRA240 hospital controlValidated FFQ-148DairyHigh vs. low0.92 (0.57–1.48)Energy, smoking, physical activity, age, calcium supplementation, history of diabetes and hypertension, cooking type, levels of salt intake, family history of cancer

Karagianni et al./2010/GreeceCases: aged 30–77, controls: 33–80, M + F52 advanced colorectal polyps52 healthy controlValidated FFQMilkLogistic regressionNAAge, sex, smoking, physical activity, BMI, waist circumference, hypercholesterolemia, alcohol, yogurt, cheese, red meat, fish, fruits, vegetables, and garlic
Yogurt0.98 (0.97–1.00)
Cheese0.96 (0.93–1.00)

Kune et al./1991/AustraliaCases: aged 68 ± 9, controls: aged 65 ± 11, M + F49 colorectal adenomatous polyps larger than 1 cm727 community controlsValidated FFQMilk drinksLogistic regressionAge, sex, vegetable, cruciferous vegetables, vitamin C, beef, pork, fish, fat, milk drinks, vitamin supplement, beer, family history of CRC in near relatives
Male3.70 (1.44–9.52)
Female1.50 (0.50–4.54)

Rifkin et al./2020/USATCPS: aged 40–75, JHBS: aged 40–85, M + FColorectal polyps TCPS: 181 SSP, 1536 AP JHBS: 96 SSP, 333 APPolyp-free controls TCPS: 3258 JHBS: 579Validated FFQ-108YogurtTCPSTCPS: sex, study location, age, regular alcohol drinking status, BMI, smoking status, physical activity in the past 10 years, educational attainment, NSAID use, red meat intake, dietary energy intake, and frequency of nonyogurt dairy intake
HBS: sex, age, cigarette use, overweight, prior colon polyp, history of cholecystectomy, diabetes mellitus diagnosis, hypertension diagnosis, hyperlipidemia diagnosis, physical activity and >10 alcohol drinks/week.
Daily vs. neverAP 0.93 (0.69–1.25)
SSP 0.49 (0.19–1.24)
≧0.20 cups vs. none/rarelyAP 0.98 (0.79–1.22)
SSP 0.77 (0.43–1.36)
JHBS
1 or more/week vs. neverAP 0.75 (0.54–1.04)
SSP 0.76 (0.44–1.29)

Senesse et al./2009/FranceAged 30–79, M + F154 small adenomas (<10 mm), 208 large adenomas (≥10 mm)427 polyp-free controlsValidated FFQMilkQ4 vs. Q1<10 mm 1.0 (0.6–1.7)Age, gender, energy intake, body mass index, alcohol, and tobacco
≧10 mm 1.0(0.7–1.7)
YogurtQ3 vs. Q1<10 mm 1.2 (0.8–2.1)
≧10 mm 0.6 (0.4–1.0)
CheeseQ4 vs. Q1<10 mm 1.0 (0.5–1.7)
≧10 mm 0.8(0.5–1.4)

Um et al./2016/USAAged 35–74, M + F787 CRA2033 polyp-free controlsValidated FFQTotal milk productsQ5 vs. Q10.99 (0.74–1.34)Study, age, sex, oxidative balance score, family history of colorectal cancer in first-degree relative, regular use of aspirin or nonsteroidal anti-inflammatory drugs, total energy intake, total fat intake (energy adjusted), supplemental calcium intake.
Total milkQ5 vs. Q10.90 (0.68–1.19)
Whole milkQ2 vs. Q11.15 (0.89–1.49)
Nonfat milkQ5 vs. Q10.92 (0.70–1.19)

Wark et al./2006/NetherlandsAged 18–75, M + F658 CRA (81 K-ras+, 453 K-Ras, 124 NA)709 polyp-free controlsValidated FFQ-178Dairy products>238.2–474.6 vs. ≦238.20.89 (0.67, 1.18)Sex, age, and total energy.
>474.6 vs. >238.2–474.60.91 (0.68, 1.22)

TCPS: Tennessee Colorectal Polyp Study; JHBS: Johns Hopkins Biofilm Study; FFQ: Food Frequency Questionnaire; AP: adenomatous polyp; SSP: sessile serrated polyp; OR: odds ratio; NA: not available; Q: quintiles.