The Human Positive Cofactor 4 is a Promising Chemotherapeutic Target in Lung Adenocarcinoma

Figure 3

PC4 decreases cisplatin’s cytotoxic effects on lung adenocarcinoma cells in vitro. (a) PC4-knockdown or PC4-overexpression LUAD cells underwent 24-hour treatment with 20 μM cisplatin. The expression of apoptotic proteins was evaluated. (b) PC4-knockdown or PC4-overexpression LUAD cells were administrated with 20 µM cisplatin for 96 hours. The CCK-8 assay was performed every 24 hours. (c), (d) PC4-knockdown or PC4-overexpression LUAD cells underwent 24-hour treatment with 0, 20, and 30 µM cisplatin. Cell apoptosis was measured and analyzed by flow cytometry.  < 0.05.

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