Genetic Variants Associated with Thyroid Cancer Risk: Comprehensive Research Synopsis, Meta-Analysis, and Cumulative Epidemiological Evidence

Table 3

OR and P value for probable significant variants with insufficient data.

Gene

Variant

Alleles

Ethnicity

MAF†

Studies

Number evaluation

Risk of meta-analysis

PQ

Sample size (case/control)

Genetic models

Effect model

OR (95%CI)

value

I (%)

CYP1A2F

rs762551

A > C

Caucasian

0.44

2

688 (170/518)

Recessive

F

1.921 (1.163 − 3.174)

≤0.01

0.0

0.55

FTO

rs1477196

G > A

Overall

0.32

2

2188 (1044/1144)

Allelic

F

1.176 (1.037 − 1.334)

≤0.01

43.7

0.18

FTO

rs8047395

A > G

Overall

0.42

2

2191 (1046/1145)

Allelic

R

1.235 (1.009 − 1.511)

0.04

61.8

0.11

FTO

rs11642841

C > A

Overall

0.18

2

2195 (1046/1149)

Allelic

F

0.784 (0.653 − 0.941)

≤0.01

38.3

0.20

FTO

rs17817288

G > A

Overall

0.44

2

2194 (1045/1149)

Recessive

F

1.410 (1.148 − 1.732)

≤0.01

0.0

0.60

IL-18-127C-T

rs360717

C > T

Overall

0.34

2

721 (130/591)

Allelic

F

1.652 (1.192 − 2.288)

≤0.01

25.4

0.27

miR-608

rs4919510

G > C

Asian

0.42

2

2975 (1193/1782)

Recessive

F

0.813 (0.664 − 0.997)

0.05

0.0

0.40

TSHR

rs1991517

A > C

Overall

0.27

2

1239 (566/673)

Allelic

F

1.250 (1.046 − 1.494)

≤0.01

0.0

0.83

XRCC3

rs56377012

A > G

Asian

0.07

2

1229 (459/770)

Recessive

F

9.421 (4.581 − 19.378)

≤0.01

0.0

0.86

F: meta-analysis was performed under the fixed-effects model. R: meta-analysis was performed under the random-effects model. Overall: two or more ethnicities were reported in the study. †Frequency of minor allele in controls.