Elevated P-Element-Induced Wimpy-Testis-Like Protein 1 Expression Predicts Unfavorable Prognosis for Patients with Various Cancers

Table 1

Main characteristics of the included studies in this meta-analysis.

Study (year)	Country	Disease	Sample size	PIWIL1		Specimens	Method	Cutoff value	Outcome	Hazard ratios	Nos.
				High	Low
Raeisossadati, 2014	Iran	CRC	46	16	30	Tissue	qRT-PCR	2 folds	CP	NR	7
Litwin, 2018	Poland	Breast cancer	101	26	75	Tissue	IHC	Score >8	OS, CP	SC	8
Sun, 2010	China	Glioma	66	34	32	Tissue	IHC	Score >3	OS, CP	SC	8
He, 2009	China	ESCC	153	28	125	Tissue	IHC	Score >4	CP	NR	8
Sun, 2017	China	CRC	110	64	46	Tissue	IHC	Intensity >1	OS, DFS, CP	MA	9
Cao, 2016	China	Breast cancer	187	89	98	Tissue	qRT-PCR	EI > 5	CSS, CP	SC	8
Yan, 2011	China	CRC	270	69	201	Tissue	IHC	>10%	OS	MA	9
Zhao, 2012	China	HCC	168	44	124	Tissue	IHC	Score >3	OS, RFS, CP	MA	9
Eckstein, 2018	Germany	Bladder cancer	95	37	58	Tissue	IHC	Score >2	CSS	MA	8
Stöhr, 2019 (1)	Germany	RCC	265	75	190	Tissue	IHC	Score >0	OS, CSS	MA	9
Stöhr, 2019 (2)	Germany	RCC	345	51	294	Tissue	IHC	Score >0	OS, CSS	MA	9
Gao, 2018	China	GC	120	80	40	Tissue	IHC	Positive cells >40%	OS, CP	MA	8
Wang, 2012	China	GC	182	NA	NA	Tissue	IHC	Score >3	OS	MA	7
Navarro, 2015	Spain	NSCLC	71	11	60	Tissue	qRT-PCR	Ct < 35	OS, RFS	MA	7

RC: colorectal cancer; ESCC: esophageal squamous cell carcinoma; HCC: hepatocellular carcinoma; RCC: renal cell carcinoma; GC: gastric cancer; NSCLC: non-small cell lung cancer; qRT-PCR: quantitative real-time polymerase chain reaction; IHC: immunohistochemistry; EI: expression index; Ct: cycle threshold; CP: clinical parameter; OS: overall survival; CSS: cancer-specific survival; DFS: disease-free survival; RFS: recurrence-free survival; NR: not reported; SC: survival curve; MA: multivariate analysis.