m6A-Mediated Tumor Invasion and Methylation Modification in Breast Cancer Microenvironment

Figure 1

Genetic mutation landscape of m6A regulatory factors in breast cancer. (a) The mutation frequency of 23 m6A regulatory factors in 986 patients with breast cancer in the TCGA-BC cohort was 5.78%. Each column represents a single patient. The bar graph above shows the tumor mutation burden, and the numbers on the right indicate the mutation frequency of each regulator. (b) Copy number variation mutation frequency of m6A regulator (blue dot, delete frequency; red dot, amplify frequency). (c) Position of copy number variation change of m6A regulatory factor on human chromosome. (d) Principal component analysis was performed on m6A regulators in the TCGA-BC cohort to distinguish tumors from normal samples. Tumor and normal samples are marked in blue and red, respectively. (e) Difference in the expression level of m6A regulatory factors between normal and tumor samples. Blue and red represent normal and tumor samples, respectively (, , and ).

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