m6A-Mediated Tumor Invasion and Methylation Modification in Breast Cancer Microenvironment

Figure 2

Pattern of m6A methylation modification in breast cancer (BC). (a) Interaction between m6A regulators in BC. Red dots represent erasers, orange dots represent readers, and gray dots represent writers. The line connecting the m6A regulatory factors represents the interaction between them. Pink represents a positive correlation, and blue represents a negative correlation. The size of each circle represents the prognostic effect of each adjustment factor and is scaled by value. Purple indicates a risk factor, and green indicates a protective factor. Using the ConsensusClusterPlus algorithm, BC samples were divided into three m6A modified subclasses, m6Aclusters A, B, and C. (b) Consensus matrix, (c) CDF graph, and (d) relative change of the area under the CDF curve when k = 2–9.

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