Systematic Pan-Cancer Population-Based Analysis Reveals the Incidence and Prognosis of Lung Metastases at Diagnosis

Table 3

Numbers of all cases, metastatic cases, and cases with pulmonary metastasis and incidence, distribution, and prognosis of lung metastasis by cancer type.

Categories		Numbers of cases			Incidence (%)		Distribution (%)	Median survival with IQR
Site	Subtype	All	Metastasis	LM	LM	LM/metastasis	Distribution of LM cases	LM
Brain	Brain	27336	280	18	0.07	6.43	0.04	10 (3–20)
Head and neck	Head and neck	65472	2969	1393	2.13	46.92	2.93	7 (3–15)
Thyroid	Thyroid	71996	1506	849	1.18	56.37	1.79	7 (2–26)
Breast	All breast	317800	22087	5391	1.70	24.41	11.34	11 (3–27)
	HR+/HER2−	214981	11133	2474	1.15	22.22	5.20	14 (4–31)
	HR+/HER2+	33561	3683	836	2.49	22.70	1.76	17 (5–31)
	HR−/HER2+	14343	2023	534	3.72	26.40	1.12	11 (3–25)
	HR−/HER2−	33931	2648	886	2.61	33.46	1.86	8 (2–15)
	Unknown	20984	2600	663	3.16	25.50	1.39	4 (1–19)
GI	Esophagus	18635	6886	1899	10.19	27.58	3.99	3 (1–8)
	Stomach	32352	8431	1707	5.28	20.25	3.59	7 (2–19)
	Small intestine	9925	1965	231	2.33	11.76	0.49	5 (1–11.5)
	Colon and rectum	174311	38217	9138	5.24	23.91	19.22	8 (2–19)
	Colon	132385	29604	6491	4.90	21.93	13.65	9 (2–23)
	Rectum	41926	8613	2647	6.31	30.73	5.57	10 (4–21)
	Anus	8389	608	190	2.26	31.25	0.40	8 (4–15)
	Liver	22420	4259	1881	8.39	44.17	3.96	2 (0–5)
	Biliary tract	8687	3148	740	8.52	23.51	1.56	3 (1–7.5)
	Pancreas	37878	21924	4238	11.19	19.33	8.92	2 (1–6)
	Head of pancreas	17871	6939	1213	6.79	17.48	2.55	3 (1–7)
	Body of pancreas	4956	3265	653	13.18	20.00	1.37	3 (1–7)
	Tail of pancreas	6693	5139	983	14.69	19.13	2.07	2 (1–5)
	Unspecified pancreas	8358	6581	1389	16.62	21.11	2.92	2 (1–5)
	Other GI	7474	4007	813	10.88	20.29	1.71	2 (0–6)
GYN	Cervix	17644	1661	783	4.44	47.14	1.65	5 (2–12)
	Endometrium	74852	3785	2056	2.75	54.32	4.33	6 (2–14)
	Ovary	26483	3302	1329	5.02	40.25	2.80	11 (2–25)
	Other GYN	11173	869	452	4.05	52.01	0.95	7 (2–21)
GU	Kidney	62992	11951	5531	8.78	46.28	11.64	6 (2–16)
	Bladder	72767	3061	1116	1.53	36.46	2.35	3 (1–8)
	Prostate	289240	14981	1247	0.43	8.32	2.62	12 (4–26)
	Testis	15736	1668	1126	7.16	67.51	2.37	19 (7–44)
	Other GU	7413	1198	468	6.31	39.07	0.98	4 (2–9)
Bone	Bone	4458	844	531	11.91	62.91	1.12	12 (5–26)
Skin	Melanoma	99708	2973	1067	1.07	35.89	2.24	4 (2–10)
Sarcoma	Sarcoma	19397	3292	1630	8.40	49.51	3.43	7 (2–19)
Others	Others	20903	5972	1713	8.19	28.68	3.60	3 (1–9)
All	All	1525441	171844	47537	3.1	27.7	100	6 (2–16)

LM: lung metastases; GI: gastrointestinal cancer; GYN: gynecologic cancer; GU: genitourinary cancer; IQR: interquartile range.