Lymph Node Metastasis-Related Gene ITGA4 Promotes the Proliferation, Migration, and Invasion of Gastric Cancer Cells by Regulating Tumor Immune Microenvironment
Table 1
Relationship between ITGA4 mRNA expression and the clinical characteristics of GC in the HMU-GC validation cohort.
Characteristic
High expression ()
Low expression ()
value
Sex, (%)
0.711
Female
38 (15.4%)
50 (20.3%)
Male
63 (25.6%)
95 (38.6%)
T classification, (%)
0.241
T1a
2 (0.8%)
4 (1.6%)
T1b
1 (0.4%)
6 (2.4%)
T2
7 (2.8%)
10 (4.1%)
T3
64 (26%)
101 (41.1%)
T4a
14 (5.7%)
16 (6.5%)
T4b
13 (5.3%)
8 (3.3%)
N classification, (%)
0.031
N0
17 (6.9%)
32 (13%)
N1
10 (4.1%)
19 (7.7%)
N2
17 (6.9%)
25 (10.2%)
N3a
28 (11.4%)
51 (20.7%)
N3b
29 (11.8%)
18 (7.3%)
M classification, (%)
0.806
M0
95 (38.6%)
134 (54.5%)
M1
6 (2.4%)
11 (4.5%)
pTNM, (%)
0.077
IA
3 (1.2%)
8 (3.3%)
IB
4 (1.6%)
6 (2.4%)
IIA
10 (4.1%)
13 (5.3%)
IIB
7 (2.8%)
16 (6.5%)
IIIA
18 (7.3%)
28 (11.4%)
IIIB
24 (9.8%)
46 (18.7%)
IIIC
29 (11.8%)
17 (6.9%)
IV
6 (2.4%)
11 (4.5%)
Borrmann type, (%)
0.307
Borrmann I
4 (1.6%)
1 (0.4%)
Borrmann II
22 (8.9%)
28 (11.4%)
Borrmann III
60 (24.4%)
89 (36.2%)
Borrmann IV
15 (6.1%)
27 (11%)
Tumor location, (%)
0.033
Lower third
41 (16.7%)
77 (31.3%)
Middle third
20 (8.1%)
35 (14.2%)
Upper third
22 (8.9%)
21 (8.5%)
Entire stomach
18 (7.3%)
12 (4.9%)
Lymphatic infiltration, (%)
0.604
Negative
46 (18.7%)
60 (24.4%)
Positive
55 (22.4%)
85 (34.6%)
Nerve infiltration, (%)
0.677
Negative
24 (9.8%)
30 (12.2%)
Positive
77 (31.3%)
115 (46.7%)
WHO classification, (%)
0.007
Mucinous
8 (3.3%)
1 (0.4%)
Poorly differentiated
26 (10.6%)
38 (15.4%)
Signet ring cell
39 (15.9%)
47 (19.1%)
Well to moderately differentiated
28 (11.4%)
59 (24%)
Age, median (IQR)
61 (51, 67)
58 (47, 64)
0.144
CEA, median (IQR)
1.81 (1.16, 3.85)
2.25 (1.27, 3.9)
0.245
CA-199, median (IQR)
10.91 (6.17, 22.47)
11.57 (5.16, 22.81)
0.714
CA724, median (IQR)
2.49 (1.29, 11.86)
3.03 (1.29, 6.64)
0.706
CA125, median (IQR)
10.21 (8.08, 13.47)
10.21 (7.72, 15.67)
0.797
Histological type, T classification, N classification, and pTNM classification were according to the AJCC 8th edition of the Cancer Staging Manual of the American Joint Committee on Cancer. Vascular infiltration, nerve infiltration, and lymphatic infiltration were determined according to the postoperative pathology report. IQR: interquartile range.
