Lymph Node Metastasis-Related Gene ITGA4 Promotes the Proliferation, Migration, and Invasion of Gastric Cancer Cells by Regulating Tumor Immune Microenvironment
Table 2
The relationship between ITGA4 expression in tumor tissue and the clinicopathological characteristics.
Characteristic
High expression ()
Low expression ()
value
Age,
0.114
BMI, median (IQR)
22.51 (20.21, 24.48)
23.19 (21.12, 25.45)
0.092
Sex, (%)
0.402
Female
16 (8.9%)
30 (16.7%)
Male
58 (32.2%)
76 (42.2%)
Tumor infiltration pattern, (%)
0.189
INFa
12 (6.7%)
24 (13.3%)
INFb
14 (7.8%)
30 (16.7%)
INFc
34 (18.9%)
34 (18.9%)
N/A
14 (7.8%)
18 (10%)
Lymphatic infiltration, (%)
0.163
Negative
47 (26.1%)
55 (30.6%)
Positive
27 (15%)
51 (28.3%)
Venous infiltration, (%)
0.936
Negative
55 (30.6%)
77 (42.8%)
Positive
19 (10.6%)
29 (16.1%)
Nerve infiltration, (%)
0.530
Negative
17 (9.4%)
30 (16.7%)
Positive
57 (31.7%)
76 (42.2%)
T classification, (%)
0.028
T1
5 (2.8%)
5 (2.8%)
T2
6 (3.3%)
21 (11.7%)
T3
24 (13.3%)
44 (24.4%)
T4
39 (21.7%)
36 (20%)
N classification, (%)
0.006
N0
18 (10%)
32 (17.8%)
N1
8 (4.4%)
28 (15.6%)
N2
17 (9.4%)
24 (13.3%)
N3
31 (17.2%)
22 (12.2%)
pTNM classification, (%)
0.109
I
9 (5%)
14 (7.8%)
II
17 (9.4%)
39 (21.7%)
III
48 (26.7%)
53 (29.4%)
Metastatic lymph node ratio, (%)
0.018
< 0.3
50 (27.8%)
90 (50%)
≥ 0.6
8 (4.4%)
4 (2.2%)
0.3 ≥, < 0.6
16 (8.9%)
12 (6.7%)
Borrmann type, (%)
0.330
Borrmann I
6 (3.3%)
9 (5%)
Borrmann II
20 (11.1%)
29 (16.1%)
Borrmann III
38 (21.1%)
62 (34.4%)
Borrmann IV
10 (5.6%)
6 (3.3%)
Lauren classification, (%)
0.514
Diffuse
30 (16.7%)
34 (18.9%)
Intestinal
17 (9.4%)
32 (17.8%)
Mixed
13 (7.2%)
23 (12.8%)
Unknown
14 (7.8%)
17 (9.4%)
Family cancer history, (%)
0.441
No
69 (38.3%)
94 (52.2%)
Yes
5 (2.8%)
12 (6.7%)
Tumor location, (%)
0.058
Entire stomach
5 (2.8%)
1 (0.6%)
Lower third
35 (19.4%)
62 (34.4%)
Middle and upper third
34 (18.9%)
43 (23.9%)
HER2 expression, (%)
0.330
Negative
61 (33.9%)
94 (52.2%)
Positive
13 (7.2%)
12 (6.7%)
CEA, (%)
0.354
> 5 ng/ml
12 (6.7%)
11 (6.1%)
≤ 5 ng/ml
62 (34.4%)
95 (52.8%)
CA19-9, (%)
0.003
> 37 U/ml
16 (8.9%)
6 (3.3%)
≤ 37 U/ml
58 (32.2%)
100 (55.6%)
CA72-4, n (%)
0.530
> 6 U/ml
17 (9.4%)
30 (16.7%)
≤ 6 U/ml
57 (31.7%)
76 (42.2%)
Histological type, T classification, N classification, and pTNM classification were according to the AJCC 8th edition of the Cancer Staging Manual of the American Joint Committee on Cancer. Vascular infiltration, nerve infiltration, and lymphatic infiltration were determined according to the postoperative pathology report. IQR: interquartile range; SD: standard deviation.
