Lymph Node Metastasis-Related Gene ITGA4 Promotes the Proliferation, Migration, and Invasion of Gastric Cancer Cells by Regulating Tumor Immune Microenvironment
Table 3
Univariate and multivariate Cox analysis of ITGA4 expression and the clinicopathological variables.
Characteristics
Total ()
Univariate analysis
Multivariate analysis
Hazard ratio (95% CI)
value
Hazard ratio (95% CI)
value
Group
100
High expression
43
Reference
Low expression
57
0.374 (0.174-0.801)
0.011
0.450 (0.206-0.984)
0.045
Sex
100
Female
28
Reference
Male
72
1.175 (0.499-2.765)
0.712
Age
100
0.992 (0.957-1.028)
0.646
BMI
100
0.944 (0.845-1.054)
0.303
Tumor infiltration pattern
100
INFc
48
Reference
INFb
16
0.843 (0.280-2.541)
0.761
INFa
20
0.568 (0.188-1.712)
0.315
N/A
16
1.035 (0.376-2.848)
0.947
Lymphatic infiltration
100
Positive
45
Reference
Negative
55
1.064 (0.503-2.249)
0.872
Venous infiltration
100
Positive
30
Reference
Negative
70
1.689 (0.685-4.166)
0.255
Nerve infiltration
100
Positive
75
Reference
Negative
25
0.446 (0.155-1.286)
0.135
T classification
100
T4
38
Reference
T3
45
0.591 (0.268-1.302)
0.192
T2
13
0.348 (0.079-1.533)
0.163
T1
4
0.585 (0.077-4.452)
0.605
Metastatic lymph node ratio
100
14.056 (3.348-59.004)
<0.001
7.032 (1.262-39.187)
0.026
Borrmann type
100
1.445 (0.769-2.715)
0.253
Tumor location
100
Lower third
54
Reference
Middle and upper third
42
1.866 (0.847-4.113)
0.122
1.369 (0.590-3.177)
0.464
Entire stomach
4
7.426 (2.017-27.337)
0.003
1.838 (0.376-8.988)
0.452
HER2
100
Positive
18
Reference
Negative
82
0.602 (0.256-1.418)
0.246
CEA
100
≤ 5 ng/ml
86
Reference
> 5 ng/ml
14
0.679 (0.205-2.250)
0.526
CA-199
100
≤ 37 U/ml
88
Reference
> 37 U/ml
12
1.745 (0.663-4.593)
0.260
CA724
100
≤ 6 U/ml
74
Reference
> 6 U/ml
26
1.096 (0.483-2.490)
0.826
Histological type and T classification were according to the AJCC 8th edition of the Cancer Staging Manual of the American Joint Committee on Cancer. Vascular infiltration, nerve infiltration, and lymphatic infiltration were determined according to the postoperative pathology report.
