High Expression of COL10A1 Is an Independent Predictive Poor Prognostic Biomarker and Associated with Immune Infiltration in Advanced Gastric Cancer Microenvironment

Table 2

Prognostic factor for OS of patients with GC determined by using univariate and multivariate COX analysis.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
T stage	362
T1&T2	96	Reference
T3&T4	266	1.719 (1.131-2.612)	0.011	1.189 (0.624-2.264)	0.599
N stage	352
N0	107	Reference
N1	97	1.629 (1.001-2.649)	0.049	1.329 (0.672-2.626)	0.413
N2	74	1.655 (0.979-2.797)	0.060	1.502 (0.650-3.469)	0.341
N3	74	2.709 (1.669-4.396)	<0.001	2.142 (0.933-4.917)	0.072
M stage	352
M0	327	Reference
M1	25	2.254 (1.295-3.924)	0.004	1.256 (0.534-2.954)	0.602
Pathologic stage	347
Stage I	50	Reference
Stage II	110	1.551 (0.782-3.078)	0.209	1.281 (0.474-3.458)	0.626
Stage III	149	2.381 (1.256-4.515)	0.008	1.256 (0.342-4.610)	0.731
Stage IV	38	3.991 (1.944-8.192)	<0.001	2.485 (0.655-9.436)	0.181
Gender	370
Female	133	Reference
Male	237	1.267 (0.891-1.804)	0.188
Age	367
≤65	163	Reference
>65	204	1.620 (1.154-2.276)	0.005	1.849 (1.272-2.687)	0.001
COL10A1	370
Low	185	Reference
High	185	1.434 (1.030-1.996)	0.033	1.567 (1.096-2.242)	0.014
Histologic grade	361
G1	10	Reference
G2	134	1.648 (0.400-6.787)	0.489
G3	217	2.174 (0.535-8.832)	0.278