Metformin Suppresses Hepatocellular Carcinoma through Regulating Alternative Splicing of LGR4

Figure 1

The level of LGR4 expression in HCC. (a)-(b). The level of LGR4 expression in HCC tumor tissues by western blotting and immunofluorescence. (c). The level of LGR4 expression in HCC cell lines. (d). Multivariate Cox analysis revealed that LGR4 in HCC tissues was an independent prognostic factor in HCC patients. ^∗, ^∗∗, ^∗∗∗.

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