Metformin Suppresses Hepatocellular Carcinoma through Regulating Alternative Splicing of LGR4

Figure 2

The role of LGR4 in HCC. (a) The expression of LGR4 was detected upon LGR4 overexpression. (a). The mRNA level of LGR4 in the LGR4 overexpressed cells. (b). The proliferation of HCC by LGR4 overexpression in HCC cell lines. (c). The migration of HCC by LGR4 overexpression in HCC cell lines; scar bar = 100 μm. (d). The invasion of HCC by LGR4 overexpression in HCC cell lines; scar bar = 50 μm. (e). The expression of catenin in LGR4 overexpressed HCC cell lines. ^∗∗, ^∗∗∗. PcDNA, an empty vector.

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