Research Article
Less Intensive Regimens May Still Be Suitable for the Initial Treatment of Primary Mediastinal B-Cell Lymphoma in Resource-Limited Settings
Table 4
Real-world data on R-CHOP versus DA-EPOCH-R in PMBCL.
| | Study | N | Consolidation RT | Survival | -value |
| | Shah et al. [25] | R-CHOP (n = 56) | R-CHOP: 59% | R-CHOP: 2 y PFS = 76% | 0.28 | | DA-EPOCH-R (n = 76) | DA-EPOCH-R: 13% | DA-EPOCH-R 28: 2 y PFS = 85% | | Malenda et al. [26] | R-CHOP (n = 25) | R-CHOP: 100% | R-CHOP: 1 y PFS = 87% | 0.2 | | DA-EPOCH-R (n = 28) | DA-EPOCH-R: 59% | DA-EPOCH-R: 5 y PFS = 73.9% | | Chan et al. [11] | R‐CHOP (n = 41) | R-CHOP: 47% | R‐CHOP: 5 y PFS = 56% | 0.02 | | R‐CHOP + RT (n = 37) | DA-EPOCH-R: 6% | R‐CHOP + RT: 5 y PFS = 90% | | DA‐EPOCH‐R (n = 46) | | DA‐EPOCH‐R: 5 y PFS = 88.5% | | Eule et al. [29] | R-CHOP (n = 9) | 100% in R-CHOP arm | 3 y OS (both arms): 96% | N.R. | | DA-EPOCH-R (n = 18) | | | | Present study | R-CHOP (n = 33) | R-CHOP: 83% | R-CHOP: 5 y PFS = 79% | 0.9 | | R-CHOEP (n = 18) | R-CHOEP: 83% | R-CHOEP: 5 y PFS = 83% | | DA-EPOCH-R (n = 39) | DA-EPOCH-R: 44% | DA-EPOCH-R: 5 y PFS = 75% |
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