GTPBP4: A New Therapeutic Target Gene Promotes Tumor Progression in Non-Small Cell Lung Cancer via EMT

Figure 6

GTPBP4 promoted NSCLC proliferation by regulating EMT. (a-b) The expression of E-cadherin protein was significantly increased, but the expression of Vimentin was significantly decreased in A549-sh-GTPBP4 group compared with the two control groups (n = 3 per group, , ^###). (c-d) The expression of E-cadherin protein was significantly increased, but the expression of Vimentin was significantly decreased in Calu−1-sh-GTPBP4 group compared with the two control groups n = 3 per group, , ^###(). (e-f) The expression of E-cadherin protein was also significantly increased and the Vimentin protein was significantly decreased in the LLC-GTPBP4 KO group compared with the LLC-WT group in mouse lung cancer tissue (n = 3 per group, ; ).

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