DNAJA1 Stabilizes EF1A1 to Promote Cell Proliferation and Metastasis of Liver Cancer Mediated by miR-205-5p

Figure 2

DNAJA1 promotes the proliferation by arresting the tumor cells at the S and G2/M phase and reducing apoptosis. (a) Representative histograms depicting cell cycle profiles of MHCC-97H and HCC-M3 cells stably transfected with DNAJA1 shRNA or negative control. (b) Representative histograms depicting cell cycle profiles of Huh 7 and HepG2 cells stably transfected with DNAJA1 overexpression vector or control vector. (c and d) The quantification of the effect of DNAJA1 on cell cycle. (e) Percent of apoptosis in Huh 7 and HepG2 cells stably transfected with DNAJA1 overexpression vector or control vector. (f) Percent of apoptosis in MHCC-97H and HCC-M3 cells stably transfected with DNAJA1 shRNA or negative control. (g and h) The quantification of the effect of DNAJA1 on apoptosis. Error bars represent from three independent experiments. .

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