ARL4C Regulates the Progression of Clear Cell Renal Cell Carcinoma by Affecting the Wnt/β-Catenin Signaling Pathway

Figure 1

Expression of ARL family genes and establishment of risk models in KIRC. (a) The differential expression of 22 ARL genes in KIRC versus normal kidney tissues. Red and blue colors in the heat map indicate high and low gene expression, respectively. The darker the color of red, the higher the gene expression; the darker the color of blue, the lower the gene expression. (b) Univariate Cox regression analysis of 22 ARL genes. (c-d) LASSO regression curve analysis and cross-validation of ARL genes. (e-f) Risk scores were calculated from linear combinations of Cox coefficients and gene expression. We divided the KIRC patients into high-risk and low-risk groups based on the best cutoff value, and the Kaplan–Meier survival curve was generated, . (g) Using the ROC curve to predict 3-year, 5-year, and 7-year survival rates. , , , and .

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