ARL4C Regulates the Progression of Clear Cell Renal Cell Carcinoma by Affecting the Wnt/β-Catenin Signaling Pathway

Figure 2

Immune infiltration, methylation, and drug sensitivity of ARL4C genes in KIRC and pan-cancers. (a) Correlation analysis between ARL mRNA expression and GDSC drug sensitivity. Red and blue colors indicate that gene expression was positively or negatively correlated, respectively, with drug sensitivity. The darker the color, the higher the correlation. (b) Methylation of ARL genes in different tumor types. Red indicates hypermethylation of the gene in the tumor, and the darker the color, the higher the methylation; blue indicates hypomethylation in the tumor, and the darker the color, the more pronounced the inhibition of methylation. (c) Correlation between different immune cells and ARL gene expression in KIRC patients. Blue represents an increase in immune infiltration with increasing gene expression, whereas red indicates that the correlation was negative. The darker the color, the higher the correlation. (d) Heat map showing the correlation of ARL gene expression with the infiltration of various immune cells in different types of pathological tumors. ; #: false discovery rate (FDR) ≤ 0.05.

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