Research Article
A Model for Predicting Clinical Prognosis in Patients with WHO Grade 2 Glioma
Table 2
Univariate and multivariate cox regression analyses of training groups.
| Variables | Univariate analyses | Multivariate analyses | HR (95% CI) | values | HR (95% CI) | values |
| Sex | | 0.442 | NA | | Male | Reference | | | | Female | 1.284 (0.678–2.430) | | | |
| Age (years) | | 0.143 | NA | | ≥40 | Reference | | | | <40 | 1.614 (0.851–3.062) | | | |
| Preoperative KPS | | <0.001 | | <0.001 | ≥80 | Reference | | Reference | | <80 | 5.376 (2.831–10.206) | | 6.648 (2.184–20.231) | |
| First presenting symptom | | <0.001 | | 0.005 | Seizures | Reference | | Reference | | Others | 7.069 (3.247–15.389) | | 3.711 (1.475–9.338) | |
| Extent of resection | | <0.001 | | 0.001 | Gross total | Reference | | Reference | | Nontotal resection or biopsy | 8.504 (3.742–19.326) | | 5.521 (1.978–15.408) | |
| Deep location | | 0.023 | | 0.217 | Yes | Reference | | Reference | | No | 0.474 (0.249–0.904) | | 2.154 (0.637–7.288) | |
| Gross tumor size | | 0.003 | | 0.009 | ≥6 cm | Reference | | Reference | | <6 cm | 0.381 (0.200–0.728) | | 0.391 (0.194–0.788) | |
| Histology | | 0.623 | NA | | Astrocytoma | Reference | | | | Oligodendroglioma | 0.852 (0.450–1.614) | | | |
| 1p19q | | 0.623 | NA | | Codeleted | Reference | | | | Not codeleted | 0.852 (0.450–1.614) | | | |
| IDH | | 0.006 | | 0.492 | Mutant | Reference | | Reference | | Wildtype | 2.678 (1.322–5.425) | | 1.360 (0.565–3.273) | |
| Chemotherapy | | 0.609 | NA | | Yes | Reference | | | | No | 1.182 (0.623–2.241) | | | |
| Radiotherapy | | <0.001 | | 0.142 | Yes | Reference | | Reference | | No | 3.567 (1.863–6.831) | | 0.366 (0.096–1.401) | |
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