Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance

<div>Verification of the hub genes (CALCRL and GNAI1) and the prognostic significance of CALCRL and GNAI1 for AML. (a) The mRNA level of GPR183, CNR2, CALCRL, and GNAI1 in four AML cell lines by RT-qPCR. (b) The protein level of CALCRL and GNAI1 in four AML cell lines and the mice tumor mass from HHT-sensitive and HHT-resistant mice groups. (c) The expression level and OS of GNAI1 and CALCRL in online database GEPIA in AML. (d) The OS and EFS of CALCRL in our cohorts. 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Journal of Oncology

fig6

Figure 6

Figure 6: Characterization of the Newly Established Homoharringtonine- (HHT-) Resistant Cell Lines and Mechanisms of Resistance 