Transmembrane Transporter Sema3D Serves as a Tumor Suppressor in Localized Clear Cell Renal Cell Carcinoma

Table 2

Univariate and multivariate Cox regression analyses of OS in 86 enrolled ccRCC patients.

Covariates	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age at surgery	1.047 (1.012 − 1.083)	0.008	1.069 (1.028 − 1.113)	0.001
Gender (male vs female)	0.871 (0.419 − 1.811)	0.711
T stage (T1 vs T2 vs T3)	2.914 (1.707 − 4.974)	<0.001	1.213 (0.476 − 3.090)	0.686
AJCC stage (I/II vs III/IV)	7.128 (2.247 − 20.938)	<0.001	5.038 (1.043 − 24.344)	0.044
Fuhrman grade (1/2 vs 3/4)	4.910 (2.305 − 10.461)	<0.001	4.208 (1.814 − 9.764)	0.001
Tumor maximal diameter	1.208 (1.070 − 1.364)	0.002	1.083 (0.939 − 1.249)	0.271
Sema3D expression (low vs high)	0.103 (0.014 − 0.755)	0.025	0.126 (0.017 − 0.942)	0.044