Transmembrane Transporter Sema3D Serves as a Tumor Suppressor in Localized Clear Cell Renal Cell Carcinoma

Table 3

Univariate and multivariate Cox regression analyses of OS in 81 enrolled localized ccRCC patients.

Covariates	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
Age at surgery	1.052 (1.013 − 1.091)	0.008	1.061 (1.020 − 1.105)	0.004
Gender (male vs female)	0.867 (0.394 − 1.910)	0.723
T stage (T1 vs T2)	3.471 (1.567 − 7.686)	0.002	1.786 (0.552 − 5.781)	0.333
Fuhrman grade (1/2 vs 3/4)	3.943 (1.694 − 9.177)	0.001	2.594 (0.923 − 7.290)	0.071
Tumor maximal diameter	1.201 (1.050 − 1.373)	0.007	1.079 (0.928 − 1.254)	0.323
Sema3D expression (low vs high)	0.114 (0.015 − 0.845)	0.034	0.125 (0.017 − 0.934)	0.043