Seven Hub Genes Predict the Prognosis of Hepatocellular Carcinoma and the Corresponding Competitive Endogenous RNA Network

Figure 5

Expression of hub genes and construction of ceRNA regulated network. (a) The log-fold change, AUC, and adjusted value of seven genes in TCGA, GSE76427, GSE62232, and GSE6764. (b) Stage, gender, event, and expressed levels were shown in HCC and control in HCC. (c) Violin plots illustrated the expression of seven hub genes. The thick black bar in the middle indicates the interquartile range, and the black line extending from it represents the 95% confidence interval. (d) Time-dependent receiver operating characteristic curve analysis displayed the AUC values over 1, 3, and 5 years. (e) Estimating the survival time of the KPNA2d by Kaplan-Meier survival curve. (f) Differentially expressed miRNAs were identified between controls and HCC samples in TCGA. Red represents upregulated miRNAs, whereas green represents downregulated miRNAs. (g) Bind sites of HCP5/has-miR-214-3p/KPNA2. Orange indicates upregulated, and yellow indicates down-regulated. HCC, hepatocellular carcinoma; AUC, area under the curve; TCGA, The Cancer Genome Atlas.

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